The unintegrated use of information technology in the cockpit of Garuda aircraft was the electronic flight bag, with the application of the Garuda electronic flight manual and the Garuda electronic airway manual. This gap would cause potential negligence and delay in distributing paper documents or manuals to the aircraft of Garuda Indonesia Airline. It was necessary to study whether the use of Garuda electronic flight manual software and Garuda electronic airway manual could ease the duties of the Pilot on board the aircraft. This research aimed to know the influence of implementing the Garuda electronic flight manual and the Garuda electronic airway manual on flight safety by optimizing human resources. The study used the Path Analysis method. The samples of this research were 30 pilots as the users and processors of the Garuda electronic flight manual and the Garuda electronic airway manual. The study found that the variable of flight safety was directly influenced by the implementation of the Garuda electronic flight manual, the Garuda electronic airway manual, and the optimization of human resources. In addition, implementing the Garuda electronic flight manual and the Garuda electronic airway manual was the variable influencing flight safety at most.