This research aimed to analyze and explain the role of the Pela Gandong culture in Maluku in improving the performance of hospital nurses in Maluku, Indonesia, through the mediation of personality and work commitment. This research used a survey method with a quantitative approach. The study was conducted at general hospitals in Maluku, Indonesia by involving 189 respondents and the analytical tool used was SEM-PLS. The results showed that the Pela Gandong culture influenced personality and work commitment but had no effect on employee performance. Meanwhile, personality and work commitment had an effect on employee performance. Thus, both personality and work commitment mediated the effect of the Pela Gandong culture on employee performance. Interestingly, the Pela Gandong culture had no effect on employee performance. However, through the mediation of personality and work commitment, the Pela Gandong culture could affect employee performance.