The evolving technology has pushed machine learning techniques to replace human smartness. A machine learning model is capable of learning and replicating like our brain. This approach of data-driven model is implemented to predict the cutting force in machining of Ti6Al4V. Titanium alloys are commonly used in high strength applications due to their excellent properties. These same properties make the machining of the titanium alloy complicated. An attempt has been made for finding the cutting force under minimum quantity lubrication (MQL). MQL is a sustainable manufacturing-based lubrication system. Taguchi’s approach was used to attain a full factorial design for combination of different parameters. Accordingly, a neural network (NN) model was developed which was capable of predicting cutting forces based on the trained model. The proposed model could be implemented to find optimal parameters in shortest duration, thereby eliminating the need for experimental computations.