In this paper, we evaluate the performance of a supply chains (SCs) under uncertainty with different components such as direct costs, operational costs, transaction expenses, order lead time, product flexibility and net profit. Data Envelopment Analysis (DEA) can be used for measuring the performance of supply chain problems. On the other hand, robust optimization approach is a powerful technique for handling problems faced with various environmental uncertainties. This paper combines these two concepts and proposes a method to evaluate SCs performance. The results of the proposed method, under any different environmental situation, show which ranking of SC’s performance is better in a network. The preliminary results of the implementation of a real-world case study indicates that the method could be successfully used for performance measurement.