The construction industry is acknowledged as one of the major primary energy consumers and contributors to global environmental emissions. To this end, proper selection of building materials is imperative to maintain the sustainability of a built environment. This research study proposed a building information modeling-based framework for lifecycle assessment of building materials in Saudi Arabia. Both Autodesk Revit and Autodesk Quantity Takeoff were adopted to define building materials, components, and their quantities. In addition, Athena Impact Estimator and Ecotect® Analysis software were leveraged to conduct thorough environmental impact assessment and energy simulation of building materials. The conducted lifecycle impact assessment tackled project phases of site preparation, construction, use, and demolition. The environmental dimensions of energy consumption, global warming, air emissions, land emissions, and water emissions were also explored. The capabilities of the developed model were tested using a case study of a college building in Saudi Arabia. The findings from this study can assist in the selection of environmentally friendly building materials that can be employed in Saudi Arabia’s construction market.