E-learning in knowledge management was examined in this study, specifically on how it assists organizations in improving knowledge transfer and e-learning management, to increase performance and employee knowledge management. In this study, e-learning and knowledge management systems and technology were jointly implemented, and its impact on organizational performance was examined. Organizational management was also explored. The present study investigated the relationship between knowledge management (KM) and innovation performance (IP). The mediating effect of knowledge Management was deeply explored. Randomly selected managers from 57 Jordanian manufacturing companies were the study samples, and there were 470 managers involved in this study, from strategic, tactical, and operational levels. Questionnaires were used to gather data, and the questionnaire items covered the constructs of knowledge management, organizational learning (OL), knowledge-oriented leadership (KOL) and IP. A research model was proposed and was tested using structural equation modeling (SEM). The findings were as follows: KOL positively affected KM; KOL positively affected IP; OL negatively affected IP; KOL positively affected KM; OL positively affected KM; KM positively affected IP and KM mediated the relationship between KOL, OL and IP.