The aim of this research is to analyze the influence of the role of AI and big data in increasing the success of e-commerce assistance and its implications for the quality of the capacity development model for MSMEs with disabilities in Serang City, Semarang City and Banjarmasin City, Indonesia. The sample in this study was 184 respondents consisting of 3 (three) regions including Serang City, Semarang City and Banjarmasin City, Indonesia. Sampling technique using technique random sampling. Data collected through questionnaires was then analyzed using SEM-PLS. The results of research and data analysis show that: The role of AI directly has a positive and significant effect on increasing the success of e-commerce assistance; Big Data directly has a positive and significant effect on increasing the success of e-commerce assistance; The role of AI directly has a positive and significant influence on the Quality of the MSME Capacity Development Model; Government Big Data directly has a positive and significant effect on the Quality of the MSME Capacity Development Model; Increasing the Success of E-Commerce Assistance directly has a positive and significant effect on the Quality of the Capacity Development Model for MSMEs with Disabilities in Serang City, Semarang City and Banjarmasin City, Indonesia. Increasing the Success of E-Commerce Assistance is able to mediate indirectly on the Role of AI and Big Data on the Quality of the Capacity Development Model for MSMEs with Disabilities in Serang City, Semarang City and Banjarmasin City, Indonesia.