There are various reasons why vaccine fear has resulted in public rejection. Students have raised concerns about vaccine effectiveness, leading to hesitation when it comes to vaccination. Vaccination apprehension impacts students' perceptions, which has an impact on the acceptability of an e-learning platform. As a result, the goal of this study is to look at the post-acceptance of an e-learning platform using a conceptual model with several factors. Every variable makes a unique contribution to the e-learning platform's post-acceptance. In the current study, TAM variables were combined with additional external factors such as fear of vaccination, perceived routine use, perceived enjoyment, perceived critical mass, and self- efficacy, all of which are directly associated with post-acceptance of an e-learning platform. Here, a hybrid conceptual model was used to evaluate the newly widespread use of e-learning platforms in this area in this study in the UAE. In the past, empirical investigations primarily used Structural Equation Modeling (SEM) analysis; however, this study used a developing hybrid analysis approach that combines SEM with deep learning–based Artificial Neural Networks (ANN). This study also employed the Importance–Performance Map Analysis (IPMA) to determine the significance and performance of each element. Through the findings, it was found that fear of vaccination, perceived ease of use, perceived usefulness, perceived routine use, perceived enjoyment, perceived critical mass, and self-efficiency all had a significant impact on students' behavioral intention to use the e-learning platform for educational purposes. It was also shown in the analysis of ANN as well as IPMA that the perceived ease of use of the e-learning platform is the most important indicator of post-acceptance. The proposed model, in theory, provides appropriate explanations for the elements that influence post-acceptance of the e-learning platform in terms of internet service factors at the individual level. In the practical sense, these findings will help decision-makers and practitioners in higher education institutions identify the factors that should be given extra care and plan their policies accordingly. The ability of the deep ANN architecture to identify the non-linear relationships between the factors involved in the theoretical model has been determined in this research. The implication offers extensive information about taking effective steps to decrease the fear of vaccination among people and increase vaccination confidence among teachers and educators and students, consequently impacting society.