For decades, entrepreneurship has become a major concern to both scholars and policymakers because of its significant role in economic and social transformation. This paper modeled the direct effects of entrepreneurial skill, environmental factors and entrepreneurial orientation on entrepreneurial intention as well as the indirect (moderating) effect of entrepreneurial orientation on the relationship of entrepreneurial skill and environmental factors with entrepreneurial intention. Quantitative research design was employed using students’ sample. It was found that entrepreneurial skill, environmental factors and entrepreneurial orientation have positive influence on entrepreneurial intention. It was also discovered that entrepreneurial orientation moderates the relationship between entrepreneurial skill and entrepreneurial intention. However, the moderation effect of entrepreneurial orientation on the relationship between environmental factors and entrepreneurial intention was not established in this study, thus, called for exploring this moderating effect in other contexts. As implication to policy, government should ensure not only enriching students with entrepreneurial skill and conducive entrepreneurial environment but also well-built entrepreneurial orientation among Nigeria teeming youths as it has a direct effect as well as strong interaction with other factors in explaining entrepreneurial intention.