The importance of entrepreneurial competencies and information technology capabilities has increased in the last few decades because of the strategic role played by the entrepreneurs. Therefore, this study aims to investigate the impact of entrepreneur competency and information technology capability on business success. A survey questionnaire was conducted to test the influence of entrepreneur competency and information technology capability. This questionnaire was filled by 403 participants who were recruited through Jordan Chamber of Commerce so as to identify the business owners who had started their companies in the recent years. The findings of the study showed that entrepreneurial competencies have a positive effect on business success and information technology which was used as a mediating role has a positive impact on both entrepreneurial competencies and business success. The findings of this research will be helpful to entrepreneurs and policy makers.