The aim of this study is twofold. First, to explore the effect of smart human resources (HR) 4.0 practices on employee effectiveness. Second, to investigate the mediating role of employee job satisfaction in the relationship between these two latent variables. Distributing a questionnaire to gather data from a sample of HR managers and employees in Ministry of Digital Economy and Entrepreneurship, the results point out that smart HR 4.0 practices as a whole construct represent a significant predictor of employee job effectiveness as measured by employee performance based on their personal, social, methodological, and technical skills. As well, the results revealed that smart HR 4.0 embodies a significant predictor of employee job satisfaction. The results found a significant effect of the latter on employee job effectiveness, a significant mediating role of employee job satisfaction was established. The study provides a theoretical basis for further studies on such effects as well as an empirical ground from which companies could start to boost employee satisfaction and effectiveness through smart HR 4.0 technologies.