This study explores how the digital business ecosystem enhances purchasing and supply management performance in the hospitality industry, focusing on the mediating role of service innovation capabilities and the moderating roles of collaborative network capabilities and knowledge sharing. Data were gathered through surveys from 401 managers of four- and five-star hotels in Türkiye, including purchasing managers and supply management professionals, and analyzed using structural equation modeling and moderated mediation analysis based on Hayes’ PROCESS macro. Digital business ecosystems positively influence purchasing and supply management performance, both directly and indirectly, via their service integration capability. Collaborative network capability and knowledge sharing serve as moderators in the research model. The findings confirm that integrating digital infrastructure, innovation capabilities, and collaborative networks improves purchasing efficiency, supplier collaboration, and overall supply management effectiveness in service-intensive environments.