Customer loyalty plays an important role for the success of aviation companies. Most airlines companies rec-ognized that a frequent flyer is about 10 times more valuable than an associational flyer. As a result, it is essen-tial to evaluate determinants of Vietnamese frequent flyers related to loyalty toward American-based airlines like Delta Air Lines. The customer loyalty was impacted by service quality, brand image, perceived value, pric-ing policy, and customer satisfaction. A sample of 300 Vietnamese frequent flyers of Delta Air Lines was col-lected for this study. The primary data was analyzed with SPSS and AMOS. The results indicate that service quality had no impact on customer loyalty of Delta Air Lines frequent flyers in Vietnam while the rest variables maintained some effects. There were several limitations of this study such as sampling, questionnaires design, and data collection. This research also contributed implications for further studies about customer loyalty in aviation industry.