This review presents the current state of knowledge on the (3+2) cycloaddition (32CA) reactions involving heteroarene N-oxides. While aromatic amine oxides behave similarly to nitrones, their participation in cycloaddition processes is chemically distinct due to the thermodynamic stability of the aromatic ring system. The manuscript critically examines these reactions, focusing on the competition between the formation of stable fused isoxazolidines and the tendency toward rearomatization. The latter often leads to spontaneous ring opening, elimination, or complex rearrangements rather than the isolation of the primary cycloadduct.

Attempts to synthesize N-phenyl-2-((5-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide was unsuccessful via cycloaddition reaction between the N-phenyl-2-thiocyanatoacetamide and benzohydrazide in the presence of Lewis acid. During this procedure, a side product, 2-(phenylamino)thiazol-4(5H)-one is obtained through intramolecular cyclization. However, nucleophilic substitution reactions performed between 5-phenyl-4H-1,2,4-triazole-3-thiol and 2-chloro-N-arylacetamides in the presence of K₂CO₃ yielded a series of 4H-1,2,4-triazole-tethered acetamides in aqueous medium. The procedure affords excellent yields of desired products containing electron-withdrawing and electron-donating groups on the aromatic rings in a short reaction time with ease of operation. The oxidation potential and photocurrent measurements of the targets indicated that the presence of the electron-withdrawing substituents afforded better results with a lower oxidation potential and higher photocurrent measurements.

The correlation between coefficients from Dimroth equations and descriptors of global electron density transfer was explored based on the data available in the recent literature. We established that the obtained results should be very usable for the interpretation of the organic reactivity and molecular mechanisms.

In this review we present recent progress in the cycloaddition reactions of conjugated nitroalkenes with alkenes, conjugated 1,3-dienes or three atoms components (eg. nitrones, azides, diazocompounds, azomethine imines and ylides).

Preliminary experiments shows, that [3+2] cycloadditions reactions proceeds with full regioselectivity and high stereoselectivity. In consequence, 3,4-trans-2-methyl-3-(3,4,5-trimethoxyphenyl)-4-halo-4-nitroisoxazolidines are forming as predominantly (or sole) products. Additionally, prognosis for the synthesized compounds to be potential ingredients of drugs is good.

Analysis of addent interactions with respect to the theory of electrophilicity and nucleophilicity indexes and kinetic studies shows the polar nature of [2+3] cycloaddition of (Z)-C-(m,m,p-trimethoxyphenyl)-N-(p-methylphenyl)-nitrone to (E)-3,3,3-trichloro-1-nitroprop-1-ene. However, PES exploration results do not confirm any zwitterion on the reaction paths. On the other hand, the nature of the solvent effect and the experimentally determined activation parameter values do not exclude a scenario in which one-step and stepwise processes occur simultaneously.