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Growing Science » Tags cloud » Benzyl α-L-rhamnopyranoside

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1.

Design and synthesis of benzyl 4-O-lauroyl-α-L-rhamnopyranoside derivatives as antimicrobial agents Pages 31-40 Right click to download the paper Download PDF

Authors: Mohammed M. Matin, Mohammad M.H. Bhuiyan, Abul K.M.S. Azad, Nishat Akther

DOI: 10.5267/j.ccl.2016.10.001

Keywords: Benzyl α-L-rhamnopyranoside, Lauroylation, Antimicrobial agents, Structure activity relationship (SAR)

Abstract:
Benzyl -L-rhamnopyranoside, prepared by both conventional and microwave assisted glycosidation techniques, was converted into benzyl 2,3-O-isopropylidene-α-L-rhamnopyranoside which after lauroylation followed by removal of isopropylidene group gave the benzyl 4-O-lauroyl-α-L-rhamnopyranoside in good yield. Several derivatives of benzyl 4-O-lauroyl-α-L-rhamnopyranoside were prepared and assessed in vitro for their antimicrobial activity against ten human pathogenic bacteria and seven fungi. The structure activity relationship (SAR) study revealed that incorporation of 4-O-lauroyl group in rhamnopyranoside frame work along with 2,3-di-O-acyl group increased the antifungal potentiality of the rhamnopyranosides.
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Journal: CCL | Year: 2017 | Volume: 6 | Issue: 1 | Views: 337 | Reviews: 0

 

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