Different metal catalysts have been tested for the one-pot transformation of carbonyl compounds, amines and phosphites to α-aminophosphonates. The influence of catalyst type, amount, solvent and the substrate electronic factor have been investigated. The results revealed that the carbonyl compounds could be smoothly converted into α-aminophosphonates at room temperature in good to excellent yields, with or without solvent in a reasonable reaction time. These results suggested that among others, lithium perchlorate and metal triflates were proven to be effective catalysts in 10 moles % catalysts. Polar aprotic solvents proved to be the best for the synthesis of α-aminophosphonates. The synthesized compounds' structure characterizations were elucidated by different spectroscopic tools and showed results consistent with the expected structures.

A novel one-pot, solvent-free method for the synthesis of dithiocarbamates was developed through the reaction of corresponding alkyl halides, amines and carbon disulfide employing catalytic amount of benzyl trimethyl ammonium hydroxide (Triton-B). The reaction conditions are milder with extremely simple work-up procedures than the reported methods, afforded high yields (82-98%) of the desired products.

The immobilized NaHSO4·H2O on activated charcoal was used as a highly efficient promoter system for facile N-formylation of amines with ethyl formate. All reactions were carried out in refluxing ethyl formate (54 ?C) under mild conditions within 10-100 min to afford the product formamides in high to excellent yields (80-94%).