Aviation safety performance at Wamena Indonesia airport is still relatively low, and this is shown by the high number of accidents that occurred at the airport in the 2013-2018 period, namely 20 accidents. The low performance of flight safety at Wamena airport is suspected to be related to the lack of optimal implementation of safety risk management and the competence of airport staff that still needs to be improved. The study aimed to determine the effect of safety risk management and airport personnel competence on flight safety performance at Wamena airport in eastern Indonesia. The research was conducted using a quantitative approach involving some respondents from airport staff and as many as 60 officers. The results showed that there was a significant direct effect of safety risk management on the flight safety performance of 79.8%; there is a significant direct effect of airport personnel competence on flight safety performance by 81.8%; there is a significant direct effect of airport personnel competence on safety risk management of 98.1%; there is a significant direct effect of safety risk management and the competence of airport personnel simultaneously on flight safety performance by 96% and based on research results show that indirectly safety risk management has an influence on flight safety performance through airport personnel competence of 97.7%.