In this study, we investigate whether transactional analysis (TA) training could improve social adjustment in a case study of women with spouses with drug addiction. This experimental study was performed on 40 people who were addicted to drugs and were under medication in some clinical centers in city of Esfahan, Iran. The patients were randomly divided into two groups (control and an experimental group). The experimental group was trained under transactional training for 8 one-hour sessions. Cronbach alpha was calculated as 0.89, which is well above the minimum acceptable. The results of the survey show that the means of two groups before test are close to each other. However, after TA has been accomplished, there is meaningful difference between these two groups. The result of F-value statistical test is also meaningful when the level of significance is five percent. In other word, there are some evidences to believe that transactional analysis training impacts on our surveyed people, positively.