The adsorption properties of hydroxyapatite of low crystallinity towards methionine have been examined. The chemical composition of hydroxyapatite was taken as an experimental variable in order to have a point of view on the parameters of the adsorption process and the mechanisms established between adsorbent-adsorbate. The adsorption kinetics are relatively fast, and the high amounts adsorbed at saturation are obtained for non-stoichiometric hydroxyapatite, containing more HPO4^2- ions and having a high specific surface area. The good agreement of the experimental data with kinetic models confirms that the mechanism can be perfectly described by pseudo-second-order kinetics. Adsorption isotherm models show that Langmuir's model gives a better fit of experimental data compared to that of Freundlich, Temkin and Dubinin-Kaganer-Radushkevich. Fourier transform infrared spectroscopy confirmed the interaction between the -COO^- ions of methionine and the Ca²⁺ ions of hydroxyapatite. The thermodynamic parameters, the isoelectric point of methionine and the point of zero charge of hydroxyapatite with different Ca/P ratios show that the adsorption process is considered spontaneous, exothermic and often controlled by physisorption with interactions electrostatic.

In the present work, Zn, Cu monometallic and bimetallic nanoparticles were synthesized using leaves extract of Borassus flabellifer. Plant extract acts as both surfactant and reducing agent. The synthesized nanoparticles were characterised by UV-Vis, XRD, FESEM, EDX, and HRTEM techniques. UV-Vis spectroscopy is used to monitor the synthesis of nanoparticles. XRD technique was used to confirm the amorphous nature of nanoparticles. The FESEM images demonstrate that the shape of the nanoparticles such as Zn monometallic (pseudo-spherical), Cu monometallic (rod), Zn-Cu bimetallic are (pseudo-spherical and rod-shaped). HRTEM images show the approximate size of the Zn, Cu monometallic and Zn-Cu bimetallic nanoparticles is 3.0 nm, 3.52 nm and 2.2 nm respectively. EDX spectra confirm the presence of Zn, Cu and O in the sample. Synthesized Zn, Cu monometallic nanoparticles, and Zn-Cu bimetallic nanoparticles were used to evaluate their possible antimicrobial, antidiabetic and antioxidant properties. Bimetallic nanoparticles displayed higher antioxidant, antidiabetic, and antimicrobial properties in the comparison of monometallic nanoparticles. The results suggest that Zn-Cu bimetallic nanoparticles have greater potential than monometallic nanoparticles.

In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity with a considerable chemical novelty. The structures of target substances were confirmed by using 1H NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds were selected by the National Cancer Institute Developmental Therapeutic Program for the in vitro cell line screening. Among all the substances tested, three compounds exhibited significant cytotoxic activity.

Nanomaterials have attracted a great deal of attention from the scientific community due to their unique properties and applications. The small size metal oxides have opened up the door for intensive research to utilize their properties for biomedical applications. Silver nanoparticle (AgNPs) and metal oxide nanomaterials like MgO, ZnO, NiO and its silver doped nanocomposites (Ag-MgO, Ag-ZnO, Ag-NiO) have been prepared using solid state combustion method using polyvinyl alcohol (PVA) as a fuel. The structure of as prepared oxides and its silver doped nanocomposites were characterized using X-ray diffraction (XRD) tool and morphology by Scanning Electron Micrograph (SEM) tool as well as Transmission electron micrograph tool respectively. Presence of the metals in the oxides and its Ag composite was confirmed by the EDX pattern. Bonding nature in the composite is well studied by the Fourier transform infrared (FT-IR) tool. Antibacterial activity studies of the nanocomposites are carried out against various bacteria.

Fused pyrimidines play an imperative role in our life due to their biological importance in the struggle of microorganisms. A series of 4-aryl-3-methyl-1-phenyl-1,4,6,7-tetrahydropyrazolo[3,4-d] thiazolo[3,2-a]pyrimidine (4a-j) were synthesized by cyclization of 3-methyl-1-phenyl-4-aryl-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-d]pyrimidine-6-thiones (3a-j) with 1,2-dibromoethane in presence of anhydrous potassium carbonate. Earlier, compounds (3a-j) were synthesized by the condensation of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (2), different substituted benzaldehyde and thiourea with catalytic amount of con. HCl in methanol. Compound 2 was synthesized by condensation of ethyl acetoacetate (1) and phenylhydrezine in presence of a catalytic amount of acetic acid at reflux temperature. The constitution of the synthesized products has been characterized by using elemental analysis, Infrared, ¹H-NMR spectroscopy and further supported by Mass spectroscopy. All the products have been screened for their in-vitro biological assay like antibacterial and antifungal activity at concentration of 500 μg/ml. It was exposed that most of the compounds displayed inspiring antibacterial and antifungal activity compared to the used reference standard.