Time-dependent response of intact intervertebral disc – In Vitro and In-Silico study on the effect of loading mode and rate

Nikkhoo, M.; Kuo, Y.; Hsu, Y.; Khalaf, K.; Haghpanahi, M.; Parnianpour, M.; Wang, J.

Growing Science » Engineering Solid Mechanics » Time-dependent response of intact intervertebral disc – In Vitro and In-Silico study on the effect of loading mode and rate

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Engineering Solid Mechanics

ISSN 2291-8752 (Online) - ISSN 2291-8744 (Print) Quarterly Publication Volume 3 Issue 1 pp. 51-58 , 2015

Time-dependent response of intact intervertebral disc – In Vitro and In-Silico study on the effect of loading mode and rate Pages 51-58 Download PDF

Authors: Mohammad Nikkhoo, Ya-Wen Kuo, Yu-Chun Hsu, Kinda Khalaf, Mohammad Haghpanahi, Mohamad Parnianpour, Jaw-Lin Wang

Keywords: Creep, Cyclic loading, Porcine intervertebral disc, Poroelastic FE model, Response surface methodology, Time-dependent response

Abstract: The investigation of dynamic response of intervertebral disc is beneficial for the development of new synthetic and engineered tissues for treating diseased or injured disc. There are limited experimental studies on comparing the effect of loading mode and rate on global response of intervertebral disc. In this study, in-vitro experiments were performed using a total of 24 porcine motion segments. The harvested specimens were assigned to prolong and 2 different cyclic loadings. Both disc deformations and water contents were measured to investigate how the mode and rate of loading affect the response of intervertebral disc. In parallel, a backward FE poroelastic model combined with in-vitro experiments were used to find the material properties of intervertebral discs. The experimental result showed that the final disc height loss under creep loading was significantly greater than cyclic groups. Increasing the frequency of cyclic loading decreased the disc height loss. The water content decreased significantly in cyclic loading from those in prolong loading. The backward FE models showed that, the elastic modulus of anulus fibrosus and nucleus pulposus were 2.43 (±0.48) MPa and 1.46 (±0.29) MPa, respectively. The hydraulic permeability was 2.08 (±0.42) ×10-16m4/Ns, and the Poisson’s ratio was 0.21 (±0.03). In conclusion, this study investigated how the loading mode and rate affect porcine intervertebral disc deformation. It is found that dynamic stiffness is greater at higher frequencies which resulted from interactions between the solid phase and fluid flow within the disc.

How to cite this paper

 Nikkhoo, M., Kuo, Y., Hsu, Y., Khalaf, K., Haghpanahi, M., Parnianpour, M & Wang, J. (2015). Time-dependent response of intact intervertebral disc – In Vitro and In-Silico study on the effect of loading mode and rate.Engineering Solid Mechanics, 3(1), 51-58.

Refrences

Argoubi, M., & Shirazi-Adl, A. (1996). Poroelastic creep response analysis of a lumbar motion segment in compression. Journal of biomechanics, 29(10), 1331-1339.

Beckstein, J. C., Sen, S., Schaer, T. P., Vresilovic, E. J., & Elliott, D. M. (2008). Comparison of animal discs used in disc research to human lumbar disc: axial compression mechanics and glycosaminoglycan content. Spine, 33(6), E166-E173.

Biot, M. A. (1941). General theory of three?dimensional consolidation. Journal of applied physics, 12(2), 155-164.

Galbusera, F., Schmidt, H., Noailly, J., Malandrino, A., Lacroix, D., Wilke, H. J., & Shirazi-Adl, A. (2011). Comparison of four methods to simulate swelling in poroelastic finite element models of intervertebral discs. Journal of the mechanical behavior of biomedical materials, 4(7), 1234-1241.

Heuer, F., Schmitt, H., Schmidt, H., Claes, L., & Wilke, H. J. (2007). Creep associated changes in intervertebral disc bulging obtained with a laser scanning device. Clinical Biomechanics, 22(7), 737-744.

Kojic, M., Filipovic, N., Vulovic, S., & Mijailovic, S. (1998). A finite element solution procedure for porous medium with fluid flow and electromechanical coupling. Communications in numerical methods in engineering, 14(4), 381-392.

Kuo, Y. W., & Wang, J. L. (2010). Rheology of intervertebral disc: an ex vivo study on the effect of loading history, loading magnitude, fatigue loading, and disc degeneration. Spine, 35(16), E743-E752.

Li, S. (1994). Response of human intervertebral discs to prolonged axial loading and low-frequency vibration. University of Illinois at Chicago

McLain, R. F., Yerby, S. A., & Moseley, T. A. (2002). Comparative morphometry of L4 vertebrae: comparison of large animal models for the human lumbar spine. Spine, 27(8), E200-E206.

Mow, V. C., Kuei, S. C., Lai, W. M., & Armstrong, C. G. (1980). Biphasic creep and stress relaxation of articular cartilage in compression: theory and experiments. Journal of biomechanical engineering, 102(1), 73-84.

Nikkhoo, M., Haghpanahi, M., Wang, J.L., and Parnianpour, M. (2011). Axisymmetric Poroelastic FE Modeling of Intervertebral Disc for Investigation of Lumbar Spine Biomechanics. Iranian Journal of Biomedical Engineering 5, 21-32.

Nikkhoo, M., Haghpanahi, M., Parnianpour, M., & Wang, J. L. (2013a). Dynamic responses of intervertebral disc during static creep and dynamic cyclic loading: a parametric poroelastic finite element analysis. Biomedical Engineering: Applications, Basis and Communications, 25(01).

Nikkhoo, M., Hsu, Y. C., Haghpanahi, M., Parnianpour, M., & Wang, J. L. (2013b). Material Property Identification of Artificial Degenerated Intervertebral Disc Models—Comparison of Inverse Poroelastic Finite Element Analysis with Biphasic Closed Form Solution. Journal of Mechanics, 29(04), 589-597.

Nikkhoo, M., Hsu, Y. C., Haghpanahi, M., Parnianpour, M., & Wang, J. L. (2013c). A meta-model analysis of a finite element simulation for defining poroelastic properties of intervertebral discs. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 0954411913480668.

Schmidt, H., Shirazi-Adl, A., Galbusera, F., & Wilke, H. J. (2010). Response analysis of the lumbar spine during regular daily activities—a finite element analysis. Journal of biomechanics, 43(10), 1849-1856.

Simon, B. R., Wu, J. S. S., Carlton, M. W., Kazarian, L. E., France, E. P., Evans, J. H., & Zienkiewicz, O. C. (1985). 1985 Volvo Award in Biomechanics: Poroelastic Dynamic Structural Models of Rhesus Spinal Motion Segments. Spine, 10(6), 494-507.

Wang, J. L., Wu, T. K., Lin, T. C., Cheng, C. H., & Huang, S. C. (2008). Rest cannot always recover the dynamic properties of fatigue-loaded intervertebral disc. Spine, 33(17), 1863-1869.

Williams, J. R., Natarajan, R. N., & Andersson, G. B. (2007). Inclusion of regional poroelastic material properties better predicts biomechanical behavior of lumbar discs subjected to dynamic loading. Journal of biomechanics, 40(9), 1981-1987.