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Growing Science » Current Chemistry Letters » Thiazole heterocycles as emerging anti-inflammatory agents: A strategic review

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Current Chemistry Letters
ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 15 Issue 3 pp. 627-646, 2026

Thiazole heterocycles as emerging anti-inflammatory agents: A strategic review Pages 627-646 PDF Download PDF

Authors: Ihor Chaban, Zoriana Chulovska, Maryan Lelyukh, Ulyana Chulovska, Taras Chaban

📋 Author Affiliations:
I. Chaban ORCID 1, Z. Сhulovska2, M. Lelyukh ORCID 1, U. Сhulovska1, T. Chaban ORCID 1
1 Danylo Halytsky Lviv National Medical University, Pekarska St. 69, Lviv, 79010, Ukraine
2 Danylo Halytsky Lviv National Medical University, Pekarska St. 69, Lviv, 79010, Ukraine, Gedeon Richter Plc., Konyskogo St.17b, Kyiv, 01054, Ukraine
doi 10.5267/j.ccl.2026.3.006
Crossref 2 Source: CrossRef

🔑 Keywords:

Abstract: Thiazole heterocycles have attracted significant attention as versatile scaffolds for the development of novel anti-inflammatory agents. Their structural diversity, ease of functionalization, and ability to interact with multiple molecular targets make them particularly attractive for addressing complex inflammatory pathologies. This review provides a comprehensive and strategic overview of thiazole-based anti-inflammatory compounds, highlighting structural classes, and mechanistic insights. Particular emphasis is placed on multi-target approaches that combine anti-inflammatory and antioxidant properties, as well as the design of prodrug and hybrid molecules aimed at improving pharmacokinetic profiles. Despite promising preclinical data, translational challenges remain, including limited in vivo validation, variability in experimental models, and gaps in ADME/toxicity profiling

How to cite this paper
APA: Chaban, I., Chulovska, Z., Lelyukh, M., Chulovska, U & Chaban, T. (2026). Thiazole heterocycles as emerging anti-inflammatory agents: A strategic review. Current Chemistry Letters, 15(3), 627-646.
Chicago/Turabian: Chaban, I., Chulovska, Z., Lelyukh, M., Chulovska, U & Chaban, T. 2026. "Thiazole heterocycles as emerging anti-inflammatory agents: A strategic review." Current Chemistry Letters 15, no. 3 (2026): 627-646.
AMA: Chaban, I., Chulovska, Z., Lelyukh, M., Chulovska, U & Chaban, T. Thiazole heterocycles as emerging anti-inflammatory agents: A strategic review. Current Chemistry Letters. 2026;15(3):627-646.

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