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How to cite this paper
APA: Shablykin, O., Kornii, Y., Bondarenko, K., Shishkina, S., Kozytskyi, A & Shablykina, O. (2026). 8-(Dichloromethylene)-3,4,7,8-tetrahydro-6H-imidazo[5,1-c][1,2,4,6]thiatriazin-6-one 2,2-dioxides: synthesis, structure and antiproliferative activity evaluation. Current Chemistry Letters, 15(3), 607-618.
Chicago/Turabian: Shablykin, O., Kornii, Y., Bondarenko, K., Shishkina, S., Kozytskyi, A & Shablykina, O. 2026. "8-(Dichloromethylene)-3,4,7,8-tetrahydro-6H-imidazo[5,1-c][1,2,4,6]thiatriazin-6-one 2,2-dioxides: synthesis, structure and antiproliferative activity evaluation." Current Chemistry Letters 15, no. 3 (2026): 607-618.
AMA: Shablykin, O., Kornii, Y., Bondarenko, K., Shishkina, S., Kozytskyi, A & Shablykina, O. 8-(Dichloromethylene)-3,4,7,8-tetrahydro-6H-imidazo[5,1-c][1,2,4,6]thiatriazin-6-one 2,2-dioxides: synthesis, structure and antiproliferative activity evaluation. Current Chemistry Letters. 2026;15(3):607-618.
References
1 Hamprecht G., Acker R.-D., Wuerzer B. (1984) 2H-1,2,4,6-Thiatriazin-3-one-1,1-dioxides and their use for controlling undesirable plant growth. US Patent 4,425,152.
2 Brzozowski Z., Sławiński J. (2007) Synthesis of 2-(4-chloro-2-mercaptobenzenesulfonyl)3,5-dihydroxy-1,1-dioxo- 2H-1,2,4,6-thiatriazine derivatives with potential anti-HIV and anticancer activities. Pol. J. Chem., 81 (8) 1419-1426.
3 Fischer C., Munoz B., Zultanski S., Methot J., Zhou H., Brown W. C. (2008) Triazole derivatives for treating Alzheimer's disease and related conditions. Patent WO2008/156580.
4 Chen W., Zhan P., De Clercq E., Pannecouque C., Balzarini J., Jiang X., Liu X. (2013) Design, synthesis and biological evaluation of N2,N4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]¬thiatriazine derivatives as HIV-1 NNRTIs. Bioorg. Med. Chem., 21 (22), 7091–7100.
5 Chaudhari S. S., Kumar S., Thomas A., Patil N. P., Kadam A. B., Waghmare N. T., Khairatkar-Joshi N., Mukhopadhyay I. (2011) Amides of heterocyclic compounds as TRPA1 inhibitors. Patent WO2011/114184.
6 Francis C. L. (2016) New heteroatom-rich ring systems from N,N-dialkyl-N'-chlorosulfonyl chloro¬formamidines Arkivoc, (i) 212-275.
7 Fischer E. (1992) Synthese, Reaktionen und Struktur Von 1,2,4,6-Thiatriazinen Sulfur reports, 11 (2) 257-313.
8 Karady S., Amato J. S., Dortmund D., Patchett A. A., Reamer R. A., Tull R. J., Weinstock L. M. (1979) Heterocycles from Chlorosulfonyl Isocyanate I. Reaction with 2-Aminoazines. Heterocycles, 12 (6) 815-818.
9 Khodachenko A., Shivanyuk A., Shishkina S., Shishkin O., Nazarenko K., Tolmachev, A. (2010) A facile synthesis of annulated thiatriazine dioxides. Synthesis, 2010 (15) 2588-2598.
10 Kornii Y., Chumachenko S., Shablykin O., Prichard M. N., James S. H., Hartline C., Zhirnov V., Brovarets V. (2019). New 2‐Oxoimidazolidine derivatives: design, synthesis and evaluation of anti‐BK virus activities in vitro. Chem. Biodiversity, 16 (10) e1900391.
11 Shablykin O. V., Kornii Y. Eu., Dyakonenko V. V., Shablykina O. V., Brovarets V. S. (2019) Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides. Curr. Chem. Lett., 8 (4) 199-210.
12 Kornii Y. Eu., Shablykin O. V., Shablykina O. V., Brovarets V. S. (2021) Synthesis New 4 iminohydantoin sulfamide derivatives with antiviral and anticancer activity. Ukr. Bioorg. Acta, 16 (1) 10-17.
13 Zhirnov V., Shablykin O., Chumachenko S., Kornii Y., Keith K. A., Harden E. A., Hartline C. B., James S. H., Kobzar O., Kovalishyn V., Vovk A., Brovarets V. (2024) In vitro activity of novel 4 iminohydantoin sulfamide derivatives against human cytomegalovirus. Chem. Pap. 78 (1) 133-140.
14 Hodyna D., Kovalishyn V., Semenyuta I., Kachaeva M., Shulha Y., Bugera M., Blagodatny V., Shablykin O., Metelytsia L. (2023) Design and Biological Evaluation of 4-Iminohydantoin Sulfamides as New Anti-Acinetobacter baumannii Agents. Biointerface Res. Appl. Chem., 13 (6) 511.
15 Chumachenko S. A., Shablykin O. V., Shishkina S. V., Kozytskyi A. V., Shablykina O. V. (2025) N-(5-(Dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfonamides: small molecules with big synthetic capabilities. Curr. Chem. Lett., 14 (4) 817-830.
16 Hu D. X., Grice P., Ley S. V. (2012) Rotamers or diastereomers? An overlooked NMR solution. J. Org. Chem. 77 (11) 5198-5202.
17 Dolomanov O. V., Bourhis L. J., Gildea R. J., Howard J. A. K., Puschmann H. (2009) OLEX2: a complete structure solution, refinement and analysis program. J. Appl. Crystallogr., 42 339-341.
18 Sheldrick G. M. (2015) SHELXT–Integrated space-group and crystal-structure determination. Acta Crystallogr. Sect. A Found. Adv., 71 3-8.
19 Sheldrick G. M. (2015) Crystal structure refinement with SHELXL. Acta Crystallogr. Sect. C, 71 3-8.
20 Velihina Ye. S., Pil'o S. G., Zyabrev V. S., Moskvina V. S., Shablykina O. V., Brovarets V. S. (2020) 2 (Dichloromethyl)pyrazolo[1,5-a][1,3,5]triazines: synthesis and anticancer activity. Biopolym. Cell., 36 (1) 61-74.
2 Brzozowski Z., Sławiński J. (2007) Synthesis of 2-(4-chloro-2-mercaptobenzenesulfonyl)3,5-dihydroxy-1,1-dioxo- 2H-1,2,4,6-thiatriazine derivatives with potential anti-HIV and anticancer activities. Pol. J. Chem., 81 (8) 1419-1426.
3 Fischer C., Munoz B., Zultanski S., Methot J., Zhou H., Brown W. C. (2008) Triazole derivatives for treating Alzheimer's disease and related conditions. Patent WO2008/156580.
4 Chen W., Zhan P., De Clercq E., Pannecouque C., Balzarini J., Jiang X., Liu X. (2013) Design, synthesis and biological evaluation of N2,N4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]¬thiatriazine derivatives as HIV-1 NNRTIs. Bioorg. Med. Chem., 21 (22), 7091–7100.
5 Chaudhari S. S., Kumar S., Thomas A., Patil N. P., Kadam A. B., Waghmare N. T., Khairatkar-Joshi N., Mukhopadhyay I. (2011) Amides of heterocyclic compounds as TRPA1 inhibitors. Patent WO2011/114184.
6 Francis C. L. (2016) New heteroatom-rich ring systems from N,N-dialkyl-N'-chlorosulfonyl chloro¬formamidines Arkivoc, (i) 212-275.
7 Fischer E. (1992) Synthese, Reaktionen und Struktur Von 1,2,4,6-Thiatriazinen Sulfur reports, 11 (2) 257-313.
8 Karady S., Amato J. S., Dortmund D., Patchett A. A., Reamer R. A., Tull R. J., Weinstock L. M. (1979) Heterocycles from Chlorosulfonyl Isocyanate I. Reaction with 2-Aminoazines. Heterocycles, 12 (6) 815-818.
9 Khodachenko A., Shivanyuk A., Shishkina S., Shishkin O., Nazarenko K., Tolmachev, A. (2010) A facile synthesis of annulated thiatriazine dioxides. Synthesis, 2010 (15) 2588-2598.
10 Kornii Y., Chumachenko S., Shablykin O., Prichard M. N., James S. H., Hartline C., Zhirnov V., Brovarets V. (2019). New 2‐Oxoimidazolidine derivatives: design, synthesis and evaluation of anti‐BK virus activities in vitro. Chem. Biodiversity, 16 (10) e1900391.
11 Shablykin O. V., Kornii Y. Eu., Dyakonenko V. V., Shablykina O. V., Brovarets V. S. (2019) Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides. Curr. Chem. Lett., 8 (4) 199-210.
12 Kornii Y. Eu., Shablykin O. V., Shablykina O. V., Brovarets V. S. (2021) Synthesis New 4 iminohydantoin sulfamide derivatives with antiviral and anticancer activity. Ukr. Bioorg. Acta, 16 (1) 10-17.
13 Zhirnov V., Shablykin O., Chumachenko S., Kornii Y., Keith K. A., Harden E. A., Hartline C. B., James S. H., Kobzar O., Kovalishyn V., Vovk A., Brovarets V. (2024) In vitro activity of novel 4 iminohydantoin sulfamide derivatives against human cytomegalovirus. Chem. Pap. 78 (1) 133-140.
14 Hodyna D., Kovalishyn V., Semenyuta I., Kachaeva M., Shulha Y., Bugera M., Blagodatny V., Shablykin O., Metelytsia L. (2023) Design and Biological Evaluation of 4-Iminohydantoin Sulfamides as New Anti-Acinetobacter baumannii Agents. Biointerface Res. Appl. Chem., 13 (6) 511.
15 Chumachenko S. A., Shablykin O. V., Shishkina S. V., Kozytskyi A. V., Shablykina O. V. (2025) N-(5-(Dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfonamides: small molecules with big synthetic capabilities. Curr. Chem. Lett., 14 (4) 817-830.
16 Hu D. X., Grice P., Ley S. V. (2012) Rotamers or diastereomers? An overlooked NMR solution. J. Org. Chem. 77 (11) 5198-5202.
17 Dolomanov O. V., Bourhis L. J., Gildea R. J., Howard J. A. K., Puschmann H. (2009) OLEX2: a complete structure solution, refinement and analysis program. J. Appl. Crystallogr., 42 339-341.
18 Sheldrick G. M. (2015) SHELXT–Integrated space-group and crystal-structure determination. Acta Crystallogr. Sect. A Found. Adv., 71 3-8.
19 Sheldrick G. M. (2015) Crystal structure refinement with SHELXL. Acta Crystallogr. Sect. C, 71 3-8.
20 Velihina Ye. S., Pil'o S. G., Zyabrev V. S., Moskvina V. S., Shablykina O. V., Brovarets V. S. (2020) 2 (Dichloromethyl)pyrazolo[1,5-a][1,3,5]triazines: synthesis and anticancer activity. Biopolym. Cell., 36 (1) 61-74.