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Growing Science » Current Chemistry Letters » Simple and fast microwave-assisted ruthenium_catalyzed direct aldol reaction

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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 1 Issue 2 pp. 91-94 , 2012

Simple and fast microwave-assisted ruthenium_catalyzed direct aldol reaction Pages 91-94 Right click to download the paper Download PDF

Authors: Elahe Keshavarz, Khalil Tabatabaeian, Manouchehr Mamaghani, Nosrat O. Mahmoodi

DOI: 10.5267/j.ccl.2012.4.001

Keywords: Aldol reaction, Catalyst, Microwave technique

Abstract: A microwave-assisted method was developed for the synthesis of aldol adducts using RuCl3.nH2O-BINAP as an efficient catalyst. Important advantages of this technology include environmentally benign condition, highly accelerated rate of the reaction with an improvement in the chemoselectivity and quality of the products.

How to cite this paper
Keshavarz, E., Tabatabaeian, K., Mamaghani, M & Mahmoodi, N. (2012). Simple and fast microwave-assisted ruthenium_catalyzed direct aldol reaction.Current Chemistry Letters, 1(2), 91-94.

Refrences
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2. Delas C., Moïse C. (2000) A Combination of Allyltitanation and Tandem Aldol-Tischtschenko Reactions using Tetraisopropoxytitanium. Synthesis, 2, 251-254.

3. Geary L. M., Hultin P. G. (2009) The State of the Art in Asymmetric Induction: the Aldol Reaction as a Case study. Tetrahedron: Asymmetry, 20(2), 131-173.

4. Chaskar A. (2012) Phosphomolybdic Acid Accelerated One-pot Synthesis of 1-Aryl-1H, 3H-thiazolo[3, 4-a]benzimidazoles. Curr. Chem. Lett., 1(1), 21-26.

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8. Chen F., Huang S., Zhang H., Liu F., Peng Y. (2008) Proline-based Dipeptides with two Amide units as Organocatalyst for the Asymmetric Aldol Reaction of Cyclohexanone with Aldehydes. Tetrahedron, 64(40), 9585-9591.

9. Siyutkin D. E., Kucherenko A. S., Zlotin S. G. (2009) Hydroxy-?-amino Acids Modified by Ionic Liquid Moieties: Recoverable Organocatalysts for Asymmetric Aldol Reactions in the Presence of Water. Tetrahedron, 65(7), 1366-1372.

10. Tzeng Z.-H., Chen H.-Y., Reddy R. J., Huang C.-T., Chen K. (2009) Highly Diastereo- and Enantioselective Direct Aldol Reactions Promoted by Water-compatible Organocatalysts Bearing a Pyrrolidinyl-camphor Structural Scaffold. Tetrahedron, 65(15), 2879-2888.

11. Masters C. (1981) Homogeneous Transition Metal Catalysis-a gentle Art, Chapman and Hall Ltd.

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13. Dou X.-Y., Wang J.-Q., Du Y., Wang E., He L.-N. (2007). Guanidinium Salt Functionalized PEG: An Effective and Recyclable Homogeneous Catalyst for the Synthesis of Cyclic Carbonates from CO2 and Epoxides under Solvent-free Conditions. Synlett, 19, 3058-3062.

14. Murahashi S.-I. (2004) Ruthenium in Organic Synthesis, Wiely-VCH: New York.

15. Murai S. (1999) Activation of Unreactive Bonds and Organic Synthesis, Springer.

16. Tabatabaeian K., Mamaghani M., Mahmoodi N. O., Keshavarz E. (2010) Facile Access to Aldol Products from Aromatic and Heteroaromatic Aldehydes using Ruthenium Catalyst. Int. J. Inorg. Chem., ID 621376, 4 pages.

17. Tabatabaeian K., Keshavarz E., Mamaghani M., Mahmoodi N. O. (2010) An Efficient RuIII/BINAP Catalytic System for the Aldol Reactions of Ketones with Various Aldehydes. Arkivoc IX, 155-162.

18. Tabatabaeian K., Keshavarz E., Mamaghani M., Mahmoodi N. O. (2011) RuCl3.nH2O as Catalyst for Diastereoselective Direct Aldol Reaction: An Efficient Route to Hormone Steroid Derivatives. Org. Chem. Int., ID, 325291, 5 pages.

19. Tabatabaeian K., Mamaghani M., Mahmoodi N. O., Keshavarz E. (2009) Ruthenium-catalyzed Cross Aldol Reaction with Aldehydes and Ketones. Arkivoc II, 68-75.

20. Wei H.-X., Jasoni R. L., Shao H., Hu J., Pare P. W. (2004) Anti-Selective and Regioselective Aldol Addition of Ketones with Aldehydes using MgI2 as Promoter. Tetrahedron, 60(51), 11829-11835.

21. Inoue H., Kikuchi M., Ito J.-I., Nishiyama H. (2008) Chiral Phebox-rhodium Complexes as Catalysts for Asymmetric Direct Aldol Reaction. Tetrahedron, 64(3), 493-499.

22. Keshavarz E., Tabatabaeian K., Mamaghani M., Mahmoodi N. O. (2011) Simple and Fast Ruthenium Catalyzed Direct Aldol Reaction: Scope and Limitations. 15th International Electronic Conference on Synthetic Organic Chemistry, (ECSOC-15).
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Journal: Current Chemistry Letters | Year: 2012 | Volume: 1 | Issue: 2 | Views: 5367 | Reviews: 0

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