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How to cite this paper
APA: Youssoufi, F., Zefzoufi, M., Elorchi, S., Alami, A., Atif, A., Mohamed, A., Salah, M., Fdil, R., Soufyane, M & Sdassi, H. (2025). New phosphonylation route of a series of 2-AlkylBenzimidazole derivatives: Synthesis, characterization, biological evaluation, ADMET prediction, molecular docking and DFT studies. Current Chemistry Letters, 14(3), 643-658.
Chicago/Turabian: Youssoufi, F., Zefzoufi, M., Elorchi, S., Alami, A., Atif, A., Mohamed, A., Salah, M., Fdil, R., Soufyane, M & Sdassi, H. 2025. "New phosphonylation route of a series of 2-AlkylBenzimidazole derivatives: Synthesis, characterization, biological evaluation, ADMET prediction, molecular docking and DFT studies." Current Chemistry Letters 14, no. 3 (2025): 643-658.
AMA: Youssoufi, F., Zefzoufi, M., Elorchi, S., Alami, A., Atif, A., Mohamed, A., Salah, M., Fdil, R., Soufyane, M & Sdassi, H. New phosphonylation route of a series of 2-AlkylBenzimidazole derivatives: Synthesis, characterization, biological evaluation, ADMET prediction, molecular docking and DFT studies. Current Chemistry Letters. 2025;14(3):643-658.
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2 Lelyukh MI, Komarenska ZM, Chaban TI, Chaban IH. (2024) An overview of the synthetic routes toward [1, 2, 4]triazolo[3,4-b][1,3,4]thiadiazoles (microreview). Chem. Heterocycl. Compd., 60(7):342-344. https://doi:10.1007/s10593-024-03343-x.
3 Prakash C, Singh R. (2024) Synthesis of fluorinated six-membered nitrogen heterocycles using microwave irradiation. Chem. Heterocycl. Compd., 60(5):216-229. https://doi:10.1007/s10593-024-03323-1.
4 Zhilitskaya LV, Yarosh NO. (2024) The synthesis of salts of five-membered heterocyclic compounds based on N-containing cations/anions (microreview). Chem. Heterocycl. Compd., 60(5):230-232. https://doi:10.1007/s10593-024-03324-0.
5 Marinescu, M.; Cinteză, L. O.; Marton, G. I.; Chifiriuc, M.-C.; Popa, M.; Stănculescu, I.; Zălaru, C.-M.; Stavarache, C.-E. (2020) Synthesis, Density Functional Theory Study and in Vitro Antimicrobial Evaluation of New Benzimidazole Mannich Bases. BMC Chem., 14 (1), 45. https://doi.org/10.1186/s13065-020-00697-z.
6 Bistrović, A.; Krstulović, L.; Stolić, I.; Drenjančević, D.; Talapko, J.; Taylor, M. C.; Kelly, J. M.; Bajić, M.; Raić-Malić, S. (2018) Synthesis, Anti-Bacterial and Anti-Protozoal Activities of Amidinobenzimidazole Derivatives and Their Interactions with DNA and RNA. J. Enzyme Inhib. Med. Chem., 33 (1), 1323–1334. https://doi.org/10.1080/14756366.2018.1484733.
7 Kenchappa, R.; Bodke, Y. D.; Telkar, S.; Aruna Sindhe, M. (2017) Antifungal and anthelmintic activity of novel benzofuran derivatives containing thiazolo benzimidazole nucleus: an in vitro evaluation. J. Chem. Bio., 10(1), 11–23. https://doi:10.1007/s12154-016-0160-x.
8 Argirova, M. A.; Georgieva, M. K.; Hristova-Avakumova, N. G.; Vuchev, D. I.; Popova-Daskalova, G. V.; K.; Anichina, K.; Yancheva, D. Y. (2021) New 1H-benzimidazole-2-yl hydrazones with combined antiparasitic and antioxidant activity. RSC Adv., 11, 39848. https://doi: 10.1039/d1ra07419a.
9 Hwu, J. R.; Singha, R.; Hong, S. C.; Chang, Y. H.; Das, A. R.; Vliegen, I.; De Clercq, E.; Neyts, J. (2008) Synthesis of New Benzimidazole–Coumarin Conjugates as Anti-Hepatitis C Virus Agents. Antiviral Res., 77 (2), 157–162. https://doi.org/10.1016/j.antiviral.2007.09.003.
10 Tremblay, M. et al. (2012) Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold. Bioorg. Med. Chem. Lett., 22(24), 7512–7517.,https://doi:10.1016/j.bmcl.2012.10.034.
11 Raka, S. C.; Rahman, A.; Hussain, F.; Abdur Rahman, S. M. (2022) Synthesis, Characterization and in Vitro, in Vivo, in Silico Biological Evaluations of Substituted Benzimidazole Derivatives. Saudi J. Biol. Sci., 29 (1), 239–250. https://doi.org/10.1016/j.sjbs.2021.08.082.
12 Shiyang, Z. and Gangliang, H. (2020) Synthesis of anti-allergic drugs. RSC Adv., 10, 5874-5885. https://doi.10.1039/C9RA10659F.
13 Yalcin-Ozkat, G. et al. (2023) Design, synthesis, and computational studies of benzimidazole derivatives as new antitubercular agents, J. Biomol. Struct. Dyn., 41, 7. https://doi.org/10.1080/07391102.2022.2036241.
14 Sahariah, M.; Chowdhury, R.; Pegu, P. et al. (2024) Design, synthesis and in-vitro anti-depressant activity evaluation of some 2-styrylbenzimidazole derivatives. Futur. J. Pharm. Sci., 10, 20. https://doi.org/10.1186/s43094-024-00589-2.
15 Sethy, S.; Mandal, S. K.; Ewies, E. F.; Dhiman, N.; Garg, A. (2021) Synthesis, Characterization and Biological Evaluation of Benzimidazole and Benzindazole Derivatives as Anti-Hypertensive Agents. Egypt. J. Chem., 64 (7), 3659–3664. https://doi.org/10.21608/ejchem.2021.79840.3931.
16 Gümrükçüoğlu, N. (2021) Synthesis and Antioxidant Properties of New Benzimidazole Derivatives. J. Polytech., 24 (4), 1699–1706. https://doi.org/10.2339/politeknik.718979.
17 Satija, G.; Sharma, B.; Madan, A.; Iqubal, A.; Shaquiquzzaman, M.; Akhter, M.; Parvez, S.; Khan, M. A.; Alam, M. M. (2022) Benzimidazole Based Derivatives as Anticancer Agents: Structure Activity Relationship Analysis for Various Targets. J. Heterocycl. Chem., 59 (1), 22–66. https://doi.org/10.1002/jhet.4355.
18 Abouelhaoul, E. A.; El Kihel, A.; Ahbala, M.; Sdassi, H.; Köhler, L. H. F.; Bauchat, P.; Roisnel, T.; Khan, T. A.; Al Nasr, I. S.; Koko, W. S.; Schobert, R.; Biersack, B. (2023) Regiospecific Reduction of 4,6-Dinitrobenzimidazoles: Synthesis, Characterization, and Biological Evaluation. Chem. Biodivers., 20 (7), e202300191. https://doi.org/10.1002/cbdv.202300191.
19 Quin, L. D. (2000) A Guide to Organophosphorus Chemistry; John Wiley & Sons.
20 Kufelnicki, A.; Woźniczka, M.; Kalinowska-Lis, U.; Jezierska, J.; Ochocki, J. (2013) Synthesis, Acid–Base and Complexing Properties with Cu(II), Co(II) and Zn(II) in Aqueous Solution of a Novel 1H-Benzimidazol-2-Ylmethyl Diethyl Phosphate Ligand: Comparison with Other 2-Substituted Benzimidazole Ligands. Polyhedron, 53, 20–25. https://doi.org/10.1016/j.poly.2013.01.006.
21 Sánchez-Moreno, M. J.; Gómez-Coca, R. B.; Fernández-Botello, A.; Ochocki, J.; Kotynski, A.; Griesser, R.; Sigel, H. (2003) Synthesis and Acid–Base Properties of (1H-Benzimidazol-2-Yl-Methyl)Phosphonate (Bimp2−). Evidence for Intramolecular Hydrogen-Bond Formation in Aqueous Solution between (N-1) H and the Phosphonate Group. Org. Biomol. Chem., 1 (10), 1819–1826. https://doi.org/10.1039/B301281F.
22 Sánchez-Moreno, M. J.; Fernández-Botello, A.; Gómez-Coca, R. B.; Griesser, R.; Ochocki, J.; Kotynski, A.; Niclós-Gutiérrez, J.; Moreno, V.; Sigel, H. (2004) Metal Ion-Binding Properties of (1H-Benzimidazol-2-Yl-Methyl)Phosphonate (Bimp2-) in Aqueous Solution. Isomeric Equilibria, Extent of Chelation, and a New Quantification Method for the Chelate Effect. Inorg. Chem., 43 (4), 1311–1322. https://doi.org/10.1021/ic030175k.
23 Tverdomed, S. N.; Kolanowski, J.; Lork, E.; Röschenthaler, G-V. (2011) An effective synthetic route to ortho difluoromethyl arylphosphosphonates: studies on the reactivity of phosphorus- and fluorine-containing functions. Tetrahedron, 67(21), 3887–3903. https://doi:10.1016/j.tet.2011.03.076.
24 Kalinowska-Lis, U.; Szewczyk, E. M.; Chęcińska, L.; Wojciechowski, J. M.; Wolf, W. M.; Ochocki, J. (2014) Synthesis, Characterization, and Antimicrobial Activity of Silver(I) and Copper (II) Complexes of Phosphate Derivatives of Pyridine And Benzimidazole. Chem. Med. Chem., 9 (1), 169–176. https://doi.org/10.1002/cmdc.201300333.
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