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Growing Science » Current Chemistry Letters » Pharmacological profile of condensed heterocyclic compounds based on functionally substituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles: A review

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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 14 Issue 3 pp. 567-578 , 2025

Pharmacological profile of condensed heterocyclic compounds based on functionally substituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles: A review Pages 567-578 Right click to download the paper Download PDF

Authors: Maryan Lelyukh, Arkady Savchenko, Myroslava Kalytovska, Maria Zhukrovska, Ihor Chaban, Andrii Vergun, Lesya Shelepeten, Taras Chaban

📋 Author Affiliations:
M. Lelyukh¹, A. Savchenko¹, I. Chaban¹, A. Vergun¹, L. Shelepeten¹, T. Chaban¹, M. Kalytovska², M. Zhukrovska²
¹ Danylo Halytsky Lviv National Medical University, Pekarska St. 69, Lviv, 79010, Ukraine
² Andrey Krupinsky Lviv Medical Academy, Doroshenko St. 70, Lviv, 79000, Ukraine
doi 10.5267/j.ccl.2025.3.001
Crossmark
2 Source: Scopus

🔑 Keywords: Heterocyclic compounds, Triazolo[3, 4b][1, 3, 4]thiadiazoles, Pharmacological activity

Abstract: Triazolo[3,4-b][1,3,4]thiadiazole molecules are found to be important tools in modern bioorganic and medicinal chemistry. This condensed system successfully combines two pharmacologically significant five-membered heterocycles – 1,2,4-triazole and 1,3,4-thiadiazole, which causes much more interest in the enhanced activity profile of its analogs than their parent separate constituents. It’s considered that the triazoles fused to thiadiazoles exhibit various therapeutically important properties, probably due to the existence of N-C-S fragments in their structures. In this review, we presented the summarized literature data about the diversity of pharmacological effects of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole based compounds as promising objects for the rational design of drug-like molecules.

How to cite this paper
APA: Lelyukh, M., Savchenko, A., Kalytovska, M., Zhukrovska, M., Chaban, I., Vergun, A., Shelepeten, L & Chaban, T. (2025). Pharmacological profile of condensed heterocyclic compounds based on functionally substituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles: A review. Current Chemistry Letters, 14(3), 567-578.
Chicago/Turabian: Lelyukh, M., Savchenko, A., Kalytovska, M., Zhukrovska, M., Chaban, I., Vergun, A., Shelepeten, L & Chaban, T. 2025. "Pharmacological profile of condensed heterocyclic compounds based on functionally substituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles: A review." Current Chemistry Letters 14, no. 3 (2025): 567-578.
AMA: Lelyukh, M., Savchenko, A., Kalytovska, M., Zhukrovska, M., Chaban, I., Vergun, A., Shelepeten, L & Chaban, T. Pharmacological profile of condensed heterocyclic compounds based on functionally substituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles: A review. Current Chemistry Letters. 2025;14(3):567-578.

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Journal: Current Chemistry Letters | Year: 2025 | Volume: 14 | Issue: 3 | Views: 312 | Reviews: 0

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