How to cite this paper
Kshatriya, M & Gajjar, J. (2025). Design and synthesis of novel benzotriazole-based hybrids with enhanced antimicrobial, antimalarial, and antitubercular potentials.Current Chemistry Letters, 14(2), 289-298.
Refrences
1. Longo Jr., L.S., and Siqueira, F.A. (2024) Synthesis of imidazo[2,1-b]thiazol-5-amines using Groebke–Blackburn–Bienaymé multicomponent reaction (microreview). Chem. Heterocycl. Compd., 1–3.
2. Lelyukh, M.I., Komarenska, Z.M., Chaban, T.I., and Chaban, I.H. (2024) An overview of the synthetic routes toward [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (microreview). Chem. Heterocycl. Compd., 1–3.
3. Liu, L., Liu, W., and Feng, H. (2024) Ring expansion strategy to access functionalized 2-oxazolines (microreview). Chem. Heterocycl. Compd., 60 (5), 236–238.
4. Bondarenko, S.S., and Lega, D.A. (2024) Recent advances in the chemistry of pyrrolidine-2,3-diones. Chem. Heterocycl. Compd., 60 (3/4), 118–120.
5. Chaban, T.I., Lelyukh, M.I., Chaban, I.H., and Kasyanchuk, O.Y. (2024) Approaches to the synthesis of thiazolo[3,2-a]pyridines. Chem. Heterocycl. Compd., 60 (3/4), 124–126.
6. Chaban, T.I., Klenina, О.V., Chaban, I.H., and Lelyukh, M.I. (2024) Recent advances in the synthesis of thiazolo[4,5-b]pyridines. Part 2: Focus on thiazole annulation to pyridine ring. Chem. Heterocycl. Compd., 60 (3/4), 130–132.
7. Kanupriya, Ravi, Mittal, and Biswas, I., Mishra (2024) Recent advances in nitrogen-containing heterocyclic scaffolds as antiviral agents. Med. Chem., DOI: 10.2174/0115734064280150231212113012.
8. Gurunathan, P.K. (2023) Nitrogen-containing heterocycles as anticancer agents: A medicinal chemistry perspective. Pharmaceuticals, DOI: 10.3390/ph16020299.
9. Lambat, T.L., Ledade, J.K., Gunjate, P.K., Bhute, A.V., Dongre, M.R., et al. (2022) Nitrogen-containing fused heterocycles: Organic synthesis and applications as potential anticancer agents. Curr. Org. Chem., DOI: 10.2174/1385272827666221227120648.
10. Ebenezer, O., Jordaan, M.M., Bono, T., Shapi, J.A., and Tuszynski, J.A. (2022) An overview of the biological evaluation of selected nitrogen-containing heterocycle medicinal chemistry compounds. Int. J. Mol. Sci., DOI: 10.3390/ijms23158117.
11. Thi, T.N.T., and Henary, M. (2022) Synthesis and applications of nitrogen-containing heterocycles as antiviral agents. Molecules, DOI: 10.3390/molecules27092700.
12. Frank, E., and Szőllősi, G. (2021) Nitrogen-containing heterocycles as significant molecular scaffolds for medicinal and other applications. Molecules, DOI: 10.3390/MOLECULES26154617.
13. Akishina, E.A., and Dikusar, E.A. (2021) Chemical modification of different compounds with nitrogen-containing heterocycles. J. Chem., DOI: 10.29235/1561-8331-2021-57-3-356-384.
14. Wang, F., Yao, Y., Zhu, H., and Zhang, Y. (2021) Nitrogen-containing heterocycle: A privileged scaffold for marketed drugs. Curr. Top. Med. Chem., DOI: 10.2174/156802662106210304105631.
15. Kaur, D., Lang, R., Arora, R., Saini, B., and Arora, S. (2020) Nitrogen-containing heterocycles as anticancer agents: An overview. Anticancer Agents Med. Chem., DOI: 10.2174/1871520620666200705214917.
16. Li, W., Zhang, J., and Zhang, J. (2020) Synthesis of heterocycles through denitrogenative cyclization of triazoles and benzotriazoles. Chem. Eur. J., DOI: 10.1002/CHEM.202000674.
17. Zhu, L., Hu, W., Wu, W., Yang, Y., and Zhang, H. (2020) Nitrogen-containing heterocyclic compounds, pharmaceutical composition, and application thereof.
18. Xia, G., Li, D., Jing, Z., Duan, L., Zuo, H., Xiao, W., et al. (2020) Nitrogenous heterocyclic compound, preparation method, intermediate, composition, and application.
19. Corona, P., Piras, S., Ibba, R., Riu, F., Murineddu, G., Sanna, G., et al. (2020) Antiviral activity of benzotriazole-based derivatives. Open Med. Chem. J., DOI: 10.2174/1874104502014010083.
20. Muthipeedika, N.J., Bakulev, V.A., and Saveliev, D. (2020) Synthesis and pharmacological study of some novel benzotriazoles containing urea. J. Chem., DOI: 10.1063/5.0018030.
21. Hu, Y., Cai, D., Dong, P., Zhu, J., Lin, K., Huang, W., et al. (2018) Nitrogen-containing heterocyclic ring compounds, preparation method, pharmaceutical compositions, and application thereof.
22. Xu, Z., Lou, Y., and Chen, L. (2018) Nitrogen-containing heterocyclic aromatic compounds and preparation methods, pharmaceutical composition, and application thereof.
23. Anand, K., and Wakode, S. (2017) Development of drugs based on benzimidazole heterocycle: Recent advancements and insights. Int. J. Chem. Stud.
24. Rono, C.K., Darkwa, J., Meyer, D., and Makhubela, E.B.C. (2019) A novel series of N-aryltriazole and N-acridinyltriazole hybrids as potential anticancer agents. Curr. Org. Synth., DOI: 10.2174/1570179416666190704112904.
25. Elsherbiny, H.E., and Radwan, E.M. (2016) New potential antitumor nitrogen heterocycles: Synthesis and cytotoxic evaluation.
26. Nirwan, N., Pareek, C., and Chohadia, A. (2015) Role of nitrogen-containing natural heterocyclic compounds in medical science: A mini review. Int. J. Sci. Res. Sci. Technol., DOI: 10.32628/IJSRST1841247.
27. Agha, K.A., Abo-Dya, N.E., Ibrahim, T.S., Abdel-Aal, E.H., and Hegazy, W.A.H. (2016) Benzotriazole-mediated synthesis and antibacterial activity of novel N-acylcephalexins. Sci. Pharm., DOI: 10.3390/SCIPHARM84030484.
28. Anjana, V.S., and Kumar, P.M. (2021) An overview on medicinal perspective and biological behavior of benzotriazole; synthetic study on its multifaceted biological activities. Int. J. Res., DOI: 10.52403/IJRR.20210546.
29. Avhad, D., Asnani, A., Mohurle, S., Kumar, P., Bais, A., and Tale, R. (2020) Review on synthetic study of benzotriazole. GSC Biol. Pharm. Sci., DOI: 10.30574/GSCBPS.2020.11.2.0137.
30. Yu, R., Zhang, L., Zhou, C., and Geng, R.X. (2014) Recent development of benzotriazole-based medicinal drugs. Med. Chem., DOI: 10.4172/2161-0444.1000207.
31. Gangurde, K.B., More, R.A., Adole, V.A., Ghotekar, D.S., et al. (2024) Design, synthesis, and biological evaluation of new benzotriazole-pyrazole clubbed thiazole hybrids as bioactive heterocycles. J. Mol. Struct., DOI: 10.1016/j.molstruc.2023.136760.
32. Nigam, J., Maiti, S., and Ganguly (2023) Some new benzotriazole derivatives: Synthesis, antimycobacterial evaluation, antimicrobial efficacy, ADME studies, and molecular docking studies. Indian J. Heterocycl. Chem., DOI: 10.59467/ijhc.2023.33.385.
2. Lelyukh, M.I., Komarenska, Z.M., Chaban, T.I., and Chaban, I.H. (2024) An overview of the synthetic routes toward [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (microreview). Chem. Heterocycl. Compd., 1–3.
3. Liu, L., Liu, W., and Feng, H. (2024) Ring expansion strategy to access functionalized 2-oxazolines (microreview). Chem. Heterocycl. Compd., 60 (5), 236–238.
4. Bondarenko, S.S., and Lega, D.A. (2024) Recent advances in the chemistry of pyrrolidine-2,3-diones. Chem. Heterocycl. Compd., 60 (3/4), 118–120.
5. Chaban, T.I., Lelyukh, M.I., Chaban, I.H., and Kasyanchuk, O.Y. (2024) Approaches to the synthesis of thiazolo[3,2-a]pyridines. Chem. Heterocycl. Compd., 60 (3/4), 124–126.
6. Chaban, T.I., Klenina, О.V., Chaban, I.H., and Lelyukh, M.I. (2024) Recent advances in the synthesis of thiazolo[4,5-b]pyridines. Part 2: Focus on thiazole annulation to pyridine ring. Chem. Heterocycl. Compd., 60 (3/4), 130–132.
7. Kanupriya, Ravi, Mittal, and Biswas, I., Mishra (2024) Recent advances in nitrogen-containing heterocyclic scaffolds as antiviral agents. Med. Chem., DOI: 10.2174/0115734064280150231212113012.
8. Gurunathan, P.K. (2023) Nitrogen-containing heterocycles as anticancer agents: A medicinal chemistry perspective. Pharmaceuticals, DOI: 10.3390/ph16020299.
9. Lambat, T.L., Ledade, J.K., Gunjate, P.K., Bhute, A.V., Dongre, M.R., et al. (2022) Nitrogen-containing fused heterocycles: Organic synthesis and applications as potential anticancer agents. Curr. Org. Chem., DOI: 10.2174/1385272827666221227120648.
10. Ebenezer, O., Jordaan, M.M., Bono, T., Shapi, J.A., and Tuszynski, J.A. (2022) An overview of the biological evaluation of selected nitrogen-containing heterocycle medicinal chemistry compounds. Int. J. Mol. Sci., DOI: 10.3390/ijms23158117.
11. Thi, T.N.T., and Henary, M. (2022) Synthesis and applications of nitrogen-containing heterocycles as antiviral agents. Molecules, DOI: 10.3390/molecules27092700.
12. Frank, E., and Szőllősi, G. (2021) Nitrogen-containing heterocycles as significant molecular scaffolds for medicinal and other applications. Molecules, DOI: 10.3390/MOLECULES26154617.
13. Akishina, E.A., and Dikusar, E.A. (2021) Chemical modification of different compounds with nitrogen-containing heterocycles. J. Chem., DOI: 10.29235/1561-8331-2021-57-3-356-384.
14. Wang, F., Yao, Y., Zhu, H., and Zhang, Y. (2021) Nitrogen-containing heterocycle: A privileged scaffold for marketed drugs. Curr. Top. Med. Chem., DOI: 10.2174/156802662106210304105631.
15. Kaur, D., Lang, R., Arora, R., Saini, B., and Arora, S. (2020) Nitrogen-containing heterocycles as anticancer agents: An overview. Anticancer Agents Med. Chem., DOI: 10.2174/1871520620666200705214917.
16. Li, W., Zhang, J., and Zhang, J. (2020) Synthesis of heterocycles through denitrogenative cyclization of triazoles and benzotriazoles. Chem. Eur. J., DOI: 10.1002/CHEM.202000674.
17. Zhu, L., Hu, W., Wu, W., Yang, Y., and Zhang, H. (2020) Nitrogen-containing heterocyclic compounds, pharmaceutical composition, and application thereof.
18. Xia, G., Li, D., Jing, Z., Duan, L., Zuo, H., Xiao, W., et al. (2020) Nitrogenous heterocyclic compound, preparation method, intermediate, composition, and application.
19. Corona, P., Piras, S., Ibba, R., Riu, F., Murineddu, G., Sanna, G., et al. (2020) Antiviral activity of benzotriazole-based derivatives. Open Med. Chem. J., DOI: 10.2174/1874104502014010083.
20. Muthipeedika, N.J., Bakulev, V.A., and Saveliev, D. (2020) Synthesis and pharmacological study of some novel benzotriazoles containing urea. J. Chem., DOI: 10.1063/5.0018030.
21. Hu, Y., Cai, D., Dong, P., Zhu, J., Lin, K., Huang, W., et al. (2018) Nitrogen-containing heterocyclic ring compounds, preparation method, pharmaceutical compositions, and application thereof.
22. Xu, Z., Lou, Y., and Chen, L. (2018) Nitrogen-containing heterocyclic aromatic compounds and preparation methods, pharmaceutical composition, and application thereof.
23. Anand, K., and Wakode, S. (2017) Development of drugs based on benzimidazole heterocycle: Recent advancements and insights. Int. J. Chem. Stud.
24. Rono, C.K., Darkwa, J., Meyer, D., and Makhubela, E.B.C. (2019) A novel series of N-aryltriazole and N-acridinyltriazole hybrids as potential anticancer agents. Curr. Org. Synth., DOI: 10.2174/1570179416666190704112904.
25. Elsherbiny, H.E., and Radwan, E.M. (2016) New potential antitumor nitrogen heterocycles: Synthesis and cytotoxic evaluation.
26. Nirwan, N., Pareek, C., and Chohadia, A. (2015) Role of nitrogen-containing natural heterocyclic compounds in medical science: A mini review. Int. J. Sci. Res. Sci. Technol., DOI: 10.32628/IJSRST1841247.
27. Agha, K.A., Abo-Dya, N.E., Ibrahim, T.S., Abdel-Aal, E.H., and Hegazy, W.A.H. (2016) Benzotriazole-mediated synthesis and antibacterial activity of novel N-acylcephalexins. Sci. Pharm., DOI: 10.3390/SCIPHARM84030484.
28. Anjana, V.S., and Kumar, P.M. (2021) An overview on medicinal perspective and biological behavior of benzotriazole; synthetic study on its multifaceted biological activities. Int. J. Res., DOI: 10.52403/IJRR.20210546.
29. Avhad, D., Asnani, A., Mohurle, S., Kumar, P., Bais, A., and Tale, R. (2020) Review on synthetic study of benzotriazole. GSC Biol. Pharm. Sci., DOI: 10.30574/GSCBPS.2020.11.2.0137.
30. Yu, R., Zhang, L., Zhou, C., and Geng, R.X. (2014) Recent development of benzotriazole-based medicinal drugs. Med. Chem., DOI: 10.4172/2161-0444.1000207.
31. Gangurde, K.B., More, R.A., Adole, V.A., Ghotekar, D.S., et al. (2024) Design, synthesis, and biological evaluation of new benzotriazole-pyrazole clubbed thiazole hybrids as bioactive heterocycles. J. Mol. Struct., DOI: 10.1016/j.molstruc.2023.136760.
32. Nigam, J., Maiti, S., and Ganguly (2023) Some new benzotriazole derivatives: Synthesis, antimycobacterial evaluation, antimicrobial efficacy, ADME studies, and molecular docking studies. Indian J. Heterocycl. Chem., DOI: 10.59467/ijhc.2023.33.385.