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Growing Science » Current Chemistry Letters » Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles

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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 12 Issue 4 pp. 813-820 , 2023

Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles Pages 813-820 Right click to download the paper Download PDF

Authors: Iryna Myrko, Taras Chaban, Yuriy Horak, Volodymyr Ogurtsov, Iryna Drapak, Ihor Chaban, Vasyl Matiychuk

DOI: 10.5267/j.ccl.2023.4.001

Keywords: Synthesis, Cyclization, [1, 2, 4]Triazolo[3, 4-b][1, 3, 4]thiadiazoles, Anticancer activity

Abstract: In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity with a considerable chemical novelty. The structures of target substances were confirmed by using 1H NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds were selected by the National Cancer Institute Developmental Therapeutic Program for the in vitro cell line screening. Among all the substances tested, three compounds exhibited significant cytotoxic activity.


How to cite this paper
Myrko, I., Chaban, T., Horak, Y., Ogurtsov, V., Drapak, I., Chaban, I & Matiychuk, V. (2023). Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles.Current Chemistry Letters, 12(4), 813-820.

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Journal: Current Chemistry Letters | Year: 2023 | Volume: 12 | Issue: 4 | Views: 1086 | Reviews: 0

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