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Growing Science » Current Chemistry Letters » Synthesis, characterization and antimicrobial activity of some new isoxazole derivatives

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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 11 Issue 3 pp. 255-262 , 2022

Synthesis, characterization and antimicrobial activity of some new isoxazole derivatives Pages 255-262 Right click to download the paper Download PDF

Authors: M. F. Dhaduk, H. S. Joshi

DOI: 10.5267/j.ccl.2022.4.004

Keywords: Isoxazoles, Antimicrobial activity, Antofungal activity, Heterocycles

Abstract: A series of isoxazole derivatives, 3-aryl-5-[5-(4-nitrophenyl)-2-furyl]-2,3-dihydroisoxazoles (5a-j) were synthesized by cyclocondensation reaction between 1-aryl-3-[5-(4-nitrophenyl)-2-furyl]prop-2-en-1-ones (4a-j) and hydroxylamine hydrochloride in presence of sodium acetate in glacial acetic acid at reflux temperature. Formerly, compounds (4a-j) were synthesized by the condensation of 5-(4-nitrophenyl) furan-2-carbaldehyde (3) with various aromatic ketones by using alkali as catalyst. The structures of the synthesized various isoxazole have been characterized by using elemental analysis, Infrared,1H-NMR spectroscopy and further supported by Mass spectroscopy. All the products have been screened for their in-vitro biological assay like antibacterial activity towards Gram-positive and Gram-negative bacterial strains and antifungal activity towards Aspergillus niger at a concentration of 40 µg/ml. It was exposed that the compounds 5a, 5c, 5e, 5f, and 5i showed inspiring antibacterial and antifungal activity compared to the used reference standard.

How to cite this paper
Dhaduk, M & Joshi, H. (2022). Synthesis, characterization and antimicrobial activity of some new isoxazole derivatives.Current Chemistry Letters, 11(3), 255-262.

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Journal: Current Chemistry Letters | Year: 2022 | Volume: 11 | Issue: 3 | Views: 1427 | Reviews: 0

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