How to cite this paper
Prabhudeva, M., Renuka, N & Kumar, K. (2018). Synthesis of thiophene-pyrazole conjugates as potent antimicrobial and radical scavengers.Current Chemistry Letters, 7(3), 73-80.
Refrences
1 Darja G., Lucija P.M., Marija S.D. (2014) Bioactivation potential of thiophene-containing drugs. Chem. Res. Toxicol. 27 (8) 1344–1358.
2 Manjunath B.C., Manjula M., Raghavendra K.R., Ajay Kumar K., Lokanath N.K. (2014) 4-(Thiophen-2-yl)-2-[4-(trifluoromethyl)-phenyl]-2,3-dihydro-1,5-benzothiazepine. Acta Cryst. Sect. E, 70 (Part 3) o261-o261.
3 Kumar G.V., Govindaraju M., Renuka N., Khatoon B.B.A., Mylarappa B.N., Kumar K.A. (2012) Synthesis of 1,3,5-triaryl-4,6-dioxo-pyrrolo[3,4-d]-7,8-dihydropyrzoles and their antimicrobial and antioxidant activity. Rasayan J. Chem. 5 (3) 338–342.
4 Ajay Kumar K., Govindaraju M., Vasantha Kumar G. (2010) Synthesis of isoxazoles via 1,3-dipolar cycloaddition reactions and their antimicrobial activity. Ind. J. Heterocycl. Chem. 20 (4) 183-184.
5 Ajay Kumar K., Lokanatha Rai K.M., Vasanth Kumar G., Mylarappa B.N. (2012) A facile route for the synthesis of ethyl N-aryl-2,6-dioxo-piperid-3-ene-4-carboxylates and their biological activity. Int. J. Pharm. Pharm. Sci. 4 (Suppl 4) 564-568.
6 Ajay Kumar K., Lokanatha Rai K.M. (2004) Synthesis and evaluation of antimicrobial activity of 4,5-dihydro-12,4-oxadiazoles, Bulg. Chem. Commun. 36 (4) 249-252.
7 Naveen S., Dileep Kumar A., Ajay Kumar K., Manjunath H.R., Lokanath N. K., Warad I. (2016) (E)-3-(2,3-Dichlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one. IUCrData, 1 (11), x161800- x161800.
8 Bukhari S.N.A., Jasamai M., Jantan I. (2012) Synthesis and biological evaluation of chalcone derivatives (mini review). Mini-Rev.Med. Chem. 12 (3) 1394–1403.
9 Kumar V., Kaur K., Gupta G.K., Sharma A.K. (2013) Pyrazole containing natural products: synthetic preview and biological significance. Eur. J. Med. Chem. 69 735–753.
10 Prabhashankar J., Govindappa V.K., Kariyappa A.K. (2013) Synthesis of 3,4-diaryl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carbonitriles via 1,3-dipolar cycloaddition reactions, Turk. J. Chem. 37 (5) 853–857.
11 Al-Saleh F.S., Al Khawaja I.K., Joule J.A. (1981) Synthesis of 4-acyl- and 4-alkoxy-carbonylpyrazoles, J. Chem. Soc. Perkin Trans. 1 642–645.
12 Govindaraju M., Mylarappa B.N., Ajay Kumar K. (2013) Synthesis of novel pyrazole derivatives and their efficacy as antimicrobial agents. Int. J. Pharm. Pharm. Sci. 5 (4), 734-737.
13 Nagamallu R., Srinivasan B., Ningappa M.B., Kariyappa A.K. (2016) Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and oxidant activities, Bioorg. Med. Chem. Lett. 26 (2) 690–694.
14 Stauffer S.R., Coletta C.J., Tedesco R., Nishiguchi G., Carlson K., Sun J., Katzenellenbogen B.S., Katzenellenbogen J.A. (2000) Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J. Med. Chem. 43 (26) 4934–4934.
15 Vijaychand S.P., Pavithra G., Raghavendra K.R., Ajay Kumar K. (2015) An efficient route to synthesis of pyrazoline carboxamides bearing thiophene moiety as antimicrobial agents. Der Pharma Chem. 7 (4) 85-89.
16 Christina Z., Florea D., Constantin D., Mircea I., Maria M., Isabela T., George M.N. (2014) Synthesis and biological screening of some 2-(1H-pyrazol-1-yl)-acetamides as lidocaine analogue. Ind. J. Chem. 53B (6) 733–739.
17 Pavithra G., Kariyappa A.K. (2016) Synthesis of bioactive furan derivatised pyrazole carboxamides and their antimicrobial and antioxidant activities, Der Pharma Chem. 8 (8) 6-11.
18 Katoch-Rouse R., Pavlova O.A., Caulder T., Hoffmann A.F., Mukhin A.G., Horti A.G. (2003) Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: Development of central cannabinoid receptor ligands with lower lipophilicity. J. Med. Chem. 46 (4) 642–645.
19 Raghavendra K.R., Renuka N., Ajay Kumar K., Shashikanth S. (2017) An accessible route for the synthesis of novel lignan derivatives and their biological evaluation. Pharm. Chem. J. 51 (8) 661-669.
20 Raghavendra K.R., Renuka N., Kameshwar V. H., Srinivasan B., Ajay Kumar K., Shashikanth S. (2016) Synthesis of lignan conjugate via cyclopropanation: Antimicrobial and antioxidant studies, Bioorg. Med. Chem. Lett. 26 (15) 3621-3625.
21 Mahadevaswamy L.D., Kariyappa A.K. (2017) An environmentally benign lemon juice mediated synthesis of novel furan conjugated pyrazole derivatives and their biological evaluation. Pharm. Chem. J. 51 (8) 670-677.
22 Lokeshwari D.M., Kameshwar V.H., Kariyappa A.K, (2017) Synthesis of furan tethered 2-pyrazolines via 1,3-dipolar cycloaddition reactions: In vitro evaluation for their antioxidant and antimicrobial activities, molecular docking and ADMET studies, Biointerface Res. App. Chem. 7(5) 2158-2165.
23 Prabhudeva M.G., Bharath S., Kumar A.D., Naveen S., Lokanath N.K., Mylarappa B.N., Kumar K.A. (2017) Design and environmentally benign synthesis of novel thiophene appended pyrazole derivatives as anti-inflammatory and radical scavenging agents: crystallographic, in silico modeling, docking and SAR characterization. Bioorg. Chem. 73 109-120.
2 Manjunath B.C., Manjula M., Raghavendra K.R., Ajay Kumar K., Lokanath N.K. (2014) 4-(Thiophen-2-yl)-2-[4-(trifluoromethyl)-phenyl]-2,3-dihydro-1,5-benzothiazepine. Acta Cryst. Sect. E, 70 (Part 3) o261-o261.
3 Kumar G.V., Govindaraju M., Renuka N., Khatoon B.B.A., Mylarappa B.N., Kumar K.A. (2012) Synthesis of 1,3,5-triaryl-4,6-dioxo-pyrrolo[3,4-d]-7,8-dihydropyrzoles and their antimicrobial and antioxidant activity. Rasayan J. Chem. 5 (3) 338–342.
4 Ajay Kumar K., Govindaraju M., Vasantha Kumar G. (2010) Synthesis of isoxazoles via 1,3-dipolar cycloaddition reactions and their antimicrobial activity. Ind. J. Heterocycl. Chem. 20 (4) 183-184.
5 Ajay Kumar K., Lokanatha Rai K.M., Vasanth Kumar G., Mylarappa B.N. (2012) A facile route for the synthesis of ethyl N-aryl-2,6-dioxo-piperid-3-ene-4-carboxylates and their biological activity. Int. J. Pharm. Pharm. Sci. 4 (Suppl 4) 564-568.
6 Ajay Kumar K., Lokanatha Rai K.M. (2004) Synthesis and evaluation of antimicrobial activity of 4,5-dihydro-12,4-oxadiazoles, Bulg. Chem. Commun. 36 (4) 249-252.
7 Naveen S., Dileep Kumar A., Ajay Kumar K., Manjunath H.R., Lokanath N. K., Warad I. (2016) (E)-3-(2,3-Dichlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one. IUCrData, 1 (11), x161800- x161800.
8 Bukhari S.N.A., Jasamai M., Jantan I. (2012) Synthesis and biological evaluation of chalcone derivatives (mini review). Mini-Rev.Med. Chem. 12 (3) 1394–1403.
9 Kumar V., Kaur K., Gupta G.K., Sharma A.K. (2013) Pyrazole containing natural products: synthetic preview and biological significance. Eur. J. Med. Chem. 69 735–753.
10 Prabhashankar J., Govindappa V.K., Kariyappa A.K. (2013) Synthesis of 3,4-diaryl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carbonitriles via 1,3-dipolar cycloaddition reactions, Turk. J. Chem. 37 (5) 853–857.
11 Al-Saleh F.S., Al Khawaja I.K., Joule J.A. (1981) Synthesis of 4-acyl- and 4-alkoxy-carbonylpyrazoles, J. Chem. Soc. Perkin Trans. 1 642–645.
12 Govindaraju M., Mylarappa B.N., Ajay Kumar K. (2013) Synthesis of novel pyrazole derivatives and their efficacy as antimicrobial agents. Int. J. Pharm. Pharm. Sci. 5 (4), 734-737.
13 Nagamallu R., Srinivasan B., Ningappa M.B., Kariyappa A.K. (2016) Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and oxidant activities, Bioorg. Med. Chem. Lett. 26 (2) 690–694.
14 Stauffer S.R., Coletta C.J., Tedesco R., Nishiguchi G., Carlson K., Sun J., Katzenellenbogen B.S., Katzenellenbogen J.A. (2000) Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J. Med. Chem. 43 (26) 4934–4934.
15 Vijaychand S.P., Pavithra G., Raghavendra K.R., Ajay Kumar K. (2015) An efficient route to synthesis of pyrazoline carboxamides bearing thiophene moiety as antimicrobial agents. Der Pharma Chem. 7 (4) 85-89.
16 Christina Z., Florea D., Constantin D., Mircea I., Maria M., Isabela T., George M.N. (2014) Synthesis and biological screening of some 2-(1H-pyrazol-1-yl)-acetamides as lidocaine analogue. Ind. J. Chem. 53B (6) 733–739.
17 Pavithra G., Kariyappa A.K. (2016) Synthesis of bioactive furan derivatised pyrazole carboxamides and their antimicrobial and antioxidant activities, Der Pharma Chem. 8 (8) 6-11.
18 Katoch-Rouse R., Pavlova O.A., Caulder T., Hoffmann A.F., Mukhin A.G., Horti A.G. (2003) Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: Development of central cannabinoid receptor ligands with lower lipophilicity. J. Med. Chem. 46 (4) 642–645.
19 Raghavendra K.R., Renuka N., Ajay Kumar K., Shashikanth S. (2017) An accessible route for the synthesis of novel lignan derivatives and their biological evaluation. Pharm. Chem. J. 51 (8) 661-669.
20 Raghavendra K.R., Renuka N., Kameshwar V. H., Srinivasan B., Ajay Kumar K., Shashikanth S. (2016) Synthesis of lignan conjugate via cyclopropanation: Antimicrobial and antioxidant studies, Bioorg. Med. Chem. Lett. 26 (15) 3621-3625.
21 Mahadevaswamy L.D., Kariyappa A.K. (2017) An environmentally benign lemon juice mediated synthesis of novel furan conjugated pyrazole derivatives and their biological evaluation. Pharm. Chem. J. 51 (8) 670-677.
22 Lokeshwari D.M., Kameshwar V.H., Kariyappa A.K, (2017) Synthesis of furan tethered 2-pyrazolines via 1,3-dipolar cycloaddition reactions: In vitro evaluation for their antioxidant and antimicrobial activities, molecular docking and ADMET studies, Biointerface Res. App. Chem. 7(5) 2158-2165.
23 Prabhudeva M.G., Bharath S., Kumar A.D., Naveen S., Lokanath N.K., Mylarappa B.N., Kumar K.A. (2017) Design and environmentally benign synthesis of novel thiophene appended pyrazole derivatives as anti-inflammatory and radical scavenging agents: crystallographic, in silico modeling, docking and SAR characterization. Bioorg. Chem. 73 109-120.