Transforming from digitalization to digitization brings many new technologies to restructure our life and life routines. In today’s competitive world, internet infrastructures and banking industries are counted as integral components for online shopping and commercial transactions. As because, disclosure of online transactions has been allowed through internet media, that would enhance the availability of electronic payment systems. Further, this study aims to explore and investigate the relationship and impact of electronic payment methods on the sales growth with the mediating role of online shopping by targeting UAE banking Industry. This study followed the quantitative approach and a correlational design. The empirical data were collected through a survey designed on a 5-point Likert scale, 217 valid questionnaires were sent to all participants (i.e., top managers, middle managers and technicians) via emails. Different statistical analyses were performed in this study. The results of the study showed high internal consistency among the study variables as Cronbach’s Alpha values ranged from .873 to .855. Further, this study highlighted the significant relationship and direct impact between online shopping and sales growth. Meanwhile, indirect impact was confirmed by the results between online shopping and sales growth through e-payment. In this regard, results can help to identify the impact of e-payment on sales growth through online shopping and also provide advantage for this and many other similar organizational studies.