The Indigenous Ghanaian woman entrepreneur, this study found exhibits many similarities with their counterparts in other countries in terms of their personality traits. However, they differed in other aspects such as their educational backgrounds and modes of entrepreneurial skills acquisition. Through their entrepreneurial activities the women have made substantial contributions to the economic growth of Ghana in terms of innovation, job creation, and reduction in poverty and unemployment. Using a survey methodology, this study concludes that to succeed as a female entrepreneur in Ghana, one requires some specific knowledge, skills and attitudes.