The research location was carried out in Garut, West Java, which is one of the potential regions for the development of leather jackets for small and medium enterprises (SMEs) in Indonesia based on its comparative advantages. Garut Regency is expected to become the home base of national leather jacket SMEs in Indonesia that are competitive and sustainable. The aim of this research was to analyze the influence of Religious Orientation (RO) on supply chain quality management through Ethics (E) as an intervening variable in Leather Jacket SMEs, Garut - West Java. What was interesting in this research and became a novelty was the inclusion of social science variables in maintaining the quality of supply chain management. In the stage of data collection, the study involved 88 entrepreneurs and leather jacket craftsmen as research respondents and processing was carried out using the Generalized Structured Component Analysis (GSCA) method. The results show that the relationship between RO variables can affect supply chain management variables, also through ethics. The implication of this research is that in running a business, to fix the quality of supply chain management, religious orientation is the important aspect.