The purpose of this study was to determine and analyze the effect of accessibility, tourism governance, and information technology on competitive advantage mediated by supply chain management at tourist destinations in Central Sulawesi Province. The research was conducted using a quantitative approach. A total of 205 respondents were used as a simple sampling technique. The data analysis technique used was Structural Equation Modeling (SEM) with Partial Least Square with the help of SmartPLS software. The results of this study indicate that accessibility, tourism governance, and information technology had positive effects on supply chain management and competitive advantage. Furthermore, supply chain management was able to mediate the effect of accessibility, tourism governance, and information technology on competitive advantage. This would practically imply that tourist attraction with easy access is more likely to increase the capability of supply chain management and competitive advantage.