The presence of heterocyclic moiety in diverse compounds, strongly indicative of the desired effect on physiological activity, and it reflects on efforts to find useful synthetic drugs. In this connection, here reporting the synthesis and characterization of 5-[substituted]-1, 3, 4-thiadiazol-2-amines (1-7). All the prepared compounds were characterized by spectroscopic viz. ¹H-NMR, ¹³C{¹H}-NMR, FT-IR, and LC-MS. The results of the DNA binding interactions using absorption and fluorescence spectroscopy reveal that the compounds are avid binders to DNA. A DNA cleavage study with pUC18 DNA using gel electrophoresis indicates the compounds are able to cleave DNA in presence of oxidant H₂O₂.

The present study focused on the Taguchi experimental design technique of Friction Stir Welds of dissimilar aluminum alloys (AA2024-T6 and AA6351-T6) for tensile properties. Effect of process parameters, rotational speed, Traverse speed and axial force, on tensile strength was evaluated. Optimized welding conditions for maximize tensile strength were estimated in order to improve the productivity, weld quality. Non-linear regression mathematical model was developed to correlate the process parameters to tensile strength. The results were verified by conducting the confirmation tests at identified optimum conditions.