This study investigates how knowledge-oriented leadership impacts on innovation performance both directly and indirectly mediated electronic based knowledge management systems (e-based KMS). Where, electronic knowledge management system consists of knowledge management infrastructures, and knowledge management processes. Primary data was obtained through a questionnaire given to 110 managers or directors of the manufacturing company as respondents. In addition, data were also obtained through observation techniques, and interviews with respondents. Both descriptive statistical analysis, and structural equation modelling (SEM) was used as an analysis method. The findings suggest that knowledge-oriented leadership has a positive, direct, and significant influence on knowledge management infrastructures as well as knowledge management processes. However, knowledge-oriented leadership has no direct influence on innovation performance. The findings also indicate that electronic knowledge management systems that consist of knowledge management infrastructures, and knowledge management processes have a direct, positive, and significant influence on innovation performance. This study suggested that there are two key pathways for businesses to improve their innovation performance i.e.: enhancing the technological, cultural, and structural infrastructure of the company, and enhancing knowledge creation, use, and utilization.