The role of leaders toward the development of entrepreneurship has been fully acknowledged. However, Leaders’ characteristics such as strategic improvisation and entrepreneurial self-efficacy were mainly examined in the private sector. Hence, it is imperative to extend empirical studies to public sector organizations. The present study, therefore, proposed and validated a model linking leaders’ strategic improvisation and entrepreneurial self-efficacy to corporate entrepreneurship in Nigerian higher education institutions (HEIs). Using a structured questionnaire, 220 responses were generated from large HEIs in Kano State, Nigeria. The data of the study was analysed using SmartPLS 3.0 to ascertain both measurement and structural model validity of the model. The results showed that both leaders’ strategic improvisation and entrepreneurial self-efficacy were significantly related to corporate entrepreneurship in HEIs. Implication and limitation of the study; and suggestions for future study are also provided.