Perishability of platelets, uncertainty of donors’ arrival and conflicting views in platelet supply chain have made platelet supply chain planning a problematic issue. In this paper, mobile blood collection system for platelet production is investigated. Two mathematical models are presented to cover the bloodmobile collection planning problem. The first model is a multi-objective fuzzy mathematical programming in which the bloodmobiles locations are considered with the aim of maximizing potential amount of blood collection and minimizing the operational cost. The second model is a vehicle routing problem with time windows which studies the shuttles routing problem. To tackle the first model, it is reformulated as a crisp multi objective linear programming model and then solved through a fuzzy multi objective programming approach. Several sensitivity analysis are conducted on important parameters to demonstrate the applicability of the proposed model. The proposed model is then solved by using a tailored Simulated Annealing (SA) algorithm. The numerical results demonstrate promising efficiency of the proposed solution method.