This work focusses on the crack growth behaviour of the compact tension specimen under mixed-mode loading, and numerical investigation using ANSYS Mechanical APDL 19.2 extended finite element software with different loading angles. The fatigue life is predicted under constant amplitude fatigue loading using the Paris’ law. The predicted values of the fatigue life in the present study provide consistency with the experimental and numerical results. In addition, the study showed that the direction of crack growth follows the same literature trend of experimental results. According to the results of the crack growth path, there is no effect of changing the geometries thicknesses on the crack growth trajectory. Its only effect is the resistance to higher plastic deformation which decreases as the thickness increases.