This study aims to analyze the factors affecting students’ attitudes and entrepreneurial intention. Quantitative approach was mainly applied with structured questionnaires directly delivered to 2,141 senior students and newly graduates from twelve universities in Ho Chi Minh City. The empirical results show that social norms, personal traits of openness to new experiences, extraversion, conscientiousness, and positive attitudes directly and indirectly affected entrepreneurial intention. In addition, agreeableness and negative attitudes negatively affected entrepreneurial intention. Based on the findings, discussions and practical implications were suggested for improving educational programs that promote the nurture of talented entrepreneurs for the country.