This paper investigates experimentally and numerically the influence of geometry and loading conditions on the fracture response of rock materials. Seven different test samples namely “Edge-Notched-Disc-Bend (ENDB), Semi-Circular-Bend (SCB), Three-Point-Bend-Inclined-Crack (TPB-IC), Single-Edge-Notched-Bending (SENB), Asymmetric-Three-Point-Bend (ATPB), Edge-Notched-Disc-Compression (ENDC) and Double-Notched-Disc-Compression (DNDC)” made of a marble rock were manufactured and tested under bending and compressive loading conditions. The results showed that the failure loads of all samples increase with the change of pure mode I to pure mode III. However, the corresponding fracture toughness values of ENDB, SCB, TPB-IC, SENB and ATPB specimens decreased, while the ENDC and DNDC samples experienced an increase in the fracture toughness. Among the studied specimens, only the ENDB, ENDC and DNDC samples presented pure mode III with KIIIc/KIc ratio ranging from 0.735 for the ENDB specimen to 2.076 for the DNDC sample. The highest mode-I fracture toughness among all the studied specimens was obtained for the SENB and TPB-IC samples, with a value of 1.54 MPa m0.5, while the lowest value was obtained for the DNDC specimen with a value of 1.21 MPa m0.5. The sign and the magnitude of T-stress considerably depended on the loading condition and geometry of the specimens. The crack trajectories of all specimens under study were also investigated.