This study aims to determine and analyze the effect of Current Ratio (CR), Debt to Assets Ratio (DAR), Net Profit Margin (NPM), Return On Equity (ROE) and Total Asset Turnover (TATO) on Profitability (ROA) in the trading, service and investment subsector companies on the Indonesia Stock Exchange (IDX) over the period 2014- 2018. The data used is panel data with 6 companies for 5 years obtained from the Annual Report published on the IDX website. The results of this study indicate that CR and DAR partially negatively affected ROA, and ROE had a positive effect on ROA, while NPM and TATO had no effect on ROA. Overall testing shows that all financial factors had a significant effect and contribute to explain changes in profitability of 89.6 percent.