The accelerated growth of cities, population increase and economic development have leveraged waste generation globally. This trend is expected to continue, with a significant increase projected in th... he coming years. Therefore, efficient waste management has become a crucial concern for local, national and international authorities. Transportation plays a key role in waste collection and disposal, being directly related to traffic congestion, fuel consumption and environmental pollution. Despite the existing studies on household waste collection, there is a gap in the literature regarding routing for residential waste collection in medium-sized cities, especially in emerging and frontier developing countries. Therefore, this study seeks through the science tree metaphor and PRISMA methodology, to find studies focused on the vehicle routing problem in waste collection operations, considering aspects such as Modeling approaches and solution techniques, applied Vehicle Routing Problems variants, objective functions, decision variables and constraints, applications in real environments, applied algorithms, and studies considering uncertainty and real conditions. A methodological outline of Vehicle Routing Problems in waste collection operations is presented, where central research topics are identified such as processes developed with Geographic Information System and their integration with exact methods, time windows, multi-objective capacitated vehicle routing problems, the application of stochastic models consider the uncertainty in waste collection, which has allowed including future prediction and optimization as prediction models, based on neural networks, to foresee uncertain conditions of the operations. This article analyzes the evolution in the optimization of municipal solid waste collection routes since 1964, highlighting the transition from iterative models to advanced technologies and multi-objective approaches. The importance of tools such as 3D Geographic Information System and heuristic/metaheuristic algorithms in improving planning and efficiency, despite limitations in the face of uncertainty, is emphasized. The systematic review shows a trend towards sustainable and efficient solutions, indicating future directions for research in urban waste management more