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Growing Science » Authors » Brijmohan Agrawal

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1.

NaCl: a facile, environmentally benign catalyst for the synthesis of pyrazole 4-carbonitrile in aqueous media Pages 57-64 Right click to download the paper Download PDF

Authors: Amol Khandebharad, Swapnil Sarda, Mahesh Soni, Charansingh Gill, Pravin Kulkarni, Brijmohan Agrawal

DOI: 10.5267/j.ccl.2018.3.003

Keywords: Aromatic aldehyde, Malononitrile, Phenyl hydrazine, Pyrazole 4-carbonitrile, Sodium chloride

Abstract:
An ecofriendly methods for the synthesis of medicinally important class of heterocyclic scaffold, pyrazole 4-carbonitrile derivatives by one pot three component reaction of malononitrile, phenyl hydrazine and aromatic aldehyde has been achieved at room temperature. Greener protocols of reaction are followed by using sodium chloride to accelerate the reaction in aqueous media. Present methodology is a condition based divergence on synthesis of pyrazole by using simple salts, which offers several advantages like use of aqueous media and high yield of product along with short reaction time, simple work up procedure, no waste or by products, avoid the use of heavy metals or nanoparticles are the fascinating characteristics of reaction.
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Journal: CCL | Year: 2018 | Volume: 7 | Issue: 2 | Views: 2182 | Reviews: 0

 

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