This study aims to examine and analyze the influence of Workload, Demographic Factors, Locus of Control, Self Esteem and Workstress on Burnout in the Senior Masinists. The research method used in this research is descriptive method. Questionnaires were distributed to 43 respondent employees of The Indonesia Railway Industry. The approach used in this research is a Variance-based Model or Structural Equation Model with a Smart-PLS analysis tool. The results show that the four variables namely Workload, Demography, Locus of Control and Work Stress had positive and significant effects on Burnout on Machinists while the Self-Esteem Variable did not have a significant effect on Burnout.