This review presents 1,3,4-oxadiazole which has considerable importance in the fields of pharmacy, medicine, corrosion and coordinate chemistry. 1,3,4-oxadiazole plays a vital role and is a simple substance for many pharmacokinetic compounds such as antifungal drugs, antibacterial drugs, most cancer tumors and anti-inflammatory drugs. This study describes many methods for the synthesis of 1,3,4-oxadiazole.