This study has tried to investigate the impact of knowledge sharing quality on E-supply chain management, with the mediating effect of E-trust. To attain the research purposes, a quantitative approach of research was applied. The needed data was collected from a sample consisting of 281 managers of Fast-Moving Consumer Goods (FMCG) companies in Jordan. A questionnaire was utilized to collect the data. Appropriate statistical analyses were conducted such as scale reliability and validity by using IBM SPSS 21 software. Structural model and hypothesis testing using AMOS software were then utilized. The results have shown that knowledge sharing quality with its main dimensions (usefulness, timeliness, accuracy, and relevance) has positive significant impacts on E-supply chain management. Besides that, E-trust has revealed a significant mediating impact between the studied independent and dependent factors. Other complementary future studies related to the practices of E-supply chain management practices, quality of knowledge sharing, and E-trust in other Jordanian organizations were also proposed.